Browsing Biomedical Engineering (Scholarly Articles) by Author "|~|"
Now showing items 21-40 of 55
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Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
Bobel, Anna C.; Lohfeld, Stefan; Shirazi, Reyhaneh Neghabat; McHugh, Peter E. (Elsevier, 2016-07-19)Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ... -
Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds
Lohfeld, Stefan; Cahill, Senan; Barron, Valerie; McHugh, Peter (2012)This paper explores the use of selective laser sintering (SLS) for the generation of bone tissue engineering scaffolds from polycaprolactone (PCL) and PCL/tricalcium phosphate (TCP). Different scaffold designs are generated, ... -
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Springer Verlag, 2013-04-09)Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ... -
A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization
Aied, Ahmed; Glynn, Barry; Cao, Hongliang; Zheng, Yu; Pandit, Abhay; Wang, Wenxin (Royal Society of Chemistry, 2012-01)The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently ... -
Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector
Mathew, Asha; Cao, Hongliang; Collin, Estelle; Wang, Wenxin; Pandit, Abhay (Elsevier, 2012-06-02)A unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) ... -
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
Freeman, Fiona E.; Haugh, Matthew G.; McNamara, Laoise M. (Mary Ann Liebert, 2015-03-03)Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ... -
Mannosylated Polyethyleneimine-Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines
Mahor, Sunil; Dash, Biraja C.; O'Connor, Stephen; Pandit, Abhay (American Chemical Society, 2012-05-02)Nonviral gene delivery systems have a number of limitations including low transfection efficiency, specificity, and cytotoxicity, especially when the target cells are macrophages. To address these issues, the hypothesis ... -
Mechanisms of osteocyte stimulation in osteoporosis
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2016-05-10)Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ... -
Micro-scale testing and micromechanical modelling for high cycle fatigue for CoCr stent material
Sweeney, Caoimhe A.; O'Brien, Barry; McHugh, Peter E. (Elsevier ScienceDirect, 2015-02-20)This paper presents a framework of experimental testing and crystal plasticity micromechanics for high cycle fatigue (HCF) of micro-scale L605 CoCr stent material. Micro-scale specimens, representative of stent struts, are ... -
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
Shirazi, Reyhaneh Neghabat; Ronan, William; Rochev, Yury; McHugh, Peter (Elsevier, 2015-09-02)Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ... -
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
Zhao, Feihu; Vaughan, Ted J.; McNamara, Laoise M. (2015-04)Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ... -
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
Ronan, William; McGarry, J. Patrick (Elsevier ScienceDirect, 2012-06-21)Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
Reynolds, Noel H.; Ronan, William; Dowling, Enda P.; McMeeking, Robert M.; McGarry, J. Patrick (Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
Mc Garrigle, M.J.; Mullen, Conleth A.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
Birmingham, Evelyn; Niebur, G.L.; McHugh, Peter E.; Shaw, G.; Barry, F.P.; McNamara, Laoise M. (AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700 °C, Part I: Literature Review
Lohfeld, Stefan; Schütze, M. (Wiley, 2005-02-04)In the first part of this paper the results of a literature review are presented. An overview of the oxidation behaviour in air and in combustion environments of both pure MoSi2 and MoSi2 composites in the temperature range ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C
Lohfeld, Stefan; Schütze, M.; Böhm, A.; Güther, V.; Rix, R.; Scholl, R. (Wiley, 2005-04-04)The topic Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C is discussed in a three part publication. In the first part of this paper a literature survey on the oxidation ... -
Oxidation behaviour of particle reinforced MoSi2 composites at temperatures up to 1700°C. Part II: Initial screening of the oxidation behaviour of MoSi2 composites
Lohfeld, Stefan; Schütze, M.; Böhm, A.; Güther, V.; Rix, R.; Scholl, R. (Wiley, 2005-03-01)In the first part of this paper a literature survey on the oxidation behaviour of MoSi2 and MoSi2 composites has been given. The present second part reports about the experimental results from oxidation tests with ... -
A physical corrosion model for bioabsorbable metal stents
Grogan, James A.; Leen, Sean B.; McHugh, Peter E. (2014)Absorbable metal stents (AMSs) are an emerging technology in the treatment of heart disease. Computational modelling of AMS performance will facilitate the development of this technology. In this study a physical corrosion ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part I: Theoretical Analysis
McGarry, Patrick; Ó Máirtín, Éamonn (2013)This paper presents a thorough analysis of potential-based and non-potential-based cohesive zone models (CZMs) under conditions of mixed-mode separation and mixed-mode over-closure. Problems are identified with the well ...