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dc.contributor.authorGorman, Adrienne M.
dc.contributor.authorCeccatelli, Sandra
dc.contributor.authorOrrenius, Sten
dc.date.accessioned2016-11-23T11:43:48Z
dc.date.available2016-11-23T11:43:48Z
dc.date.issued2000-12
dc.identifier.citationGorman, A. M., Ceccatelli, S., & Orrenius, S. (2000). Role of Mitochondria in Neuronal Apoptosis. Developmental Neuroscience, 22(5-6), 348-358. DOI:10.1159/000017460en_IE
dc.identifier.issn1421-9859
dc.identifier.urihttp://hdl.handle.net/10379/6167
dc.description.abstractApoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis. They house a number of apoptogenic molecules that are released into the cytoplasm at the onset of apoptosis. These include cytochrome c, apoptosis-inducing factor and various caspases. Mitochondria also play an important role in intracellular Ca2+ regulation, which is crucial to excitotoxic neurodegeneration. Alterations in energy (ATP) production by mitochondria (due to hypoxia or mutations in genes encoding mitochondrial proteins of the electron transport chain) can induce apoptosis in neurons or increase their sensitivity to apoptosis.en_IE
dc.description.sponsorshipThis work was supported by a grant from the Swedish Fund for Research without Animals (CFN) and by a fellowship (to A.G.) from the Karolinska Institute.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherKarger Publishersen_IE
dc.relation.ispartofDevelopmental Neuroscienceen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectApoptosisen_IE
dc.subjectMitochondriaen_IE
dc.subjectNeuronal apoptosisen_IE
dc.subjectCaspaseen_IE
dc.subjectCytochromeen_IE
dc.subjectc Hypoxiaen_IE
dc.titleRole of mitochondria in neuronal apoptosisen_IE
dc.typeArticleen_IE
dc.date.updated2016-11-23T10:26:35Z
dc.identifier.doi10.1159/000017460
dc.local.publishedsourcehttp:/dx.doi.org/10.1159/000017460en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid1145669
dc.local.contactAdrienne Gorman, Biochemistry, School Of Natural Science, Bioresearch Building, Nui. 2417 Email: adrienne.gorman@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland