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dc.contributor.authorKenney, Joanne
dc.contributor.authorAnderson-Schmidt, Heike
dc.contributor.authorScanlon, Cathy
dc.contributor.authorArndt, Sophia
dc.contributor.authorScherz, Elisabeth
dc.contributor.authorMcInerney, Shane
dc.contributor.authorMcFarland, John
dc.contributor.authorByrne, Fintan
dc.contributor.authorAhmed, Mohamed
dc.contributor.authorDonohoe, Gary
dc.contributor.authorHallahan, Brian
dc.contributor.authorMcDonald, Colm
dc.contributor.authorCannon, Dara M.
dc.date.accessioned2016-11-08T09:53:13Z
dc.date.available2016-11-08T09:53:13Z
dc.date.issued2015-09-26
dc.identifier.citationKenney, Joanne, Anderson-Schmidt, Heike, Scanlon, Cathy, Arndt, Sophia, Scherz, Elisabeth, McInerney, Shane, McFarland, John, Byrne, Fintan, Ahmed, Mohamed, Donohoe, Gary, Hallahan, Brian, McDonald, Colm, Cannon, Dara M. (2015). Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery. Schizophrenia Research, 169(1–3), 101-108. doi: http://dx.doi.org/10.1016/j.schres.2015.09.007en_IE
dc.identifier.issn1573-2509
dc.identifier.urihttp://hdl.handle.net/10379/6144
dc.description.abstractWhile cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment. Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices. Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance. In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course..en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.relation.ispartofSchizophrenia Researchen
dc.subjectFirst-episode psychosisen_IE
dc.subjectCognitionen_IE
dc.subjectClinicalen_IE
dc.subjectLongitudinalen_IE
dc.subjectMATRICS Consensus Cognitive Batteryen_IE
dc.subjectPsychiatryen_IE
dc.titleCognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.en_IE
dc.typeArticleen_IE
dc.date.updated2016-11-08T09:36:39Z
dc.identifier.doi10.1016/j.schres.2015.09.007
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.schres.2015.09.007en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid9874647
dc.local.contactDara Cannon, Anatomy, Nui, Galway. 5692 Email: dara.cannon@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
nui.item.downloads566


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