Show simple item record

dc.contributor.authorKenney, Joanne
dc.contributor.authorAnderson-Schmidt, Heike
dc.contributor.authorScanlon, Cathy
dc.contributor.authorArndt, Sophia
dc.contributor.authorScherz, Elisabeth
dc.contributor.authorMcInerney, Shane
dc.contributor.authorMcFarland, John
dc.contributor.authorByrne, Fintan
dc.contributor.authorAhmed, Mohamed
dc.contributor.authorDonohoe, Gary
dc.contributor.authorHallahan, Brian
dc.contributor.authorMcDonald, Colm
dc.contributor.authorCannon, Dara M.
dc.identifier.citationKenney, Joanne, Anderson-Schmidt, Heike, Scanlon, Cathy, Arndt, Sophia, Scherz, Elisabeth, McInerney, Shane, McFarland, John, Byrne, Fintan, Ahmed, Mohamed, Donohoe, Gary, Hallahan, Brian, McDonald, Colm, Cannon, Dara M. (2015). Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery. Schizophrenia Research, 169(1–3), 101-108. doi:
dc.description.abstractWhile cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment. Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices. Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance. In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course..en_IE
dc.relation.ispartofSchizophrenia Researchen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectFirst-episode psychosisen_IE
dc.subjectMATRICS Consensus Cognitive Batteryen_IE
dc.titleCognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.en_IE
dc.local.contactDara Cannon, Anatomy, Nui, Galway. 5692 Email:

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland