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dc.contributor.authorMurphy, Paul V.
dc.date.accessioned2016-10-24T11:09:41Z
dc.date.available2016-10-24T11:09:41Z
dc.date.issued2016-05-13
dc.identifier.citationR. Roy, P. V. Murphy, and H.-J. Gabius (2016) 'Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition'. Molecules (Basel, Switzerland), 21 .en_IE
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10379/6094
dc.descriptionJournal articleen_IE
dc.description.abstractGlycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. Studies toward this aim will also help appraise the potential for lectin-directed drug design. With the network of adhesion/growth-regulatory galectins as therapeutic targets, the strategy to recruit synthetic chemistry to systematically elucidate structure-activity relationships is outlined, from monovalent compounds to glyco-clusters and glycodendrimers to biomimetic surfaces. The versatility of the synthetic procedures enables to take examining structural and spatial parameters, alone and in combination, to its limits, for example with the aim to produce inhibitors for distinct galectin(s) that exhibit minimal reactivity to other members of this group. Shaping spatial architectures similar to glycoconjugate aggregates, microdomains or vesicles provides attractive tools to disclose the often still hidden significance of nanometric aspects of the different modes of lectin design (sequence divergence at the lectin site, differences of spatial type of lectin-site presentation). Of note, testing the effectors alone or in combination simulating (patho)physiological conditions, is sure to bring about new insights into the cooperation between lectins and the regulation of their activity.en_IE
dc.description.sponsorshipScience Foundation Ireland (08/SRC/B1393 & 12/IA/1398); European Regional Development Fund (Grant No. 14/SP/2710)en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherMDPI Open Accessen_IE
dc.relation.ispartofMolecules (Basel, Switzerland)en
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectAgglutininen_IE
dc.subjectGalectinen_IE
dc.subjectGlycoclusteren_IE
dc.subjectGlycodendrimeren_IE
dc.subjectGlycophaneen_IE
dc.subjectGlycoproteinen_IE
dc.subjectLiposomesen_IE
dc.subjectOligosaccharidesen_IE
dc.subjectSugar codeen_IE
dc.titleMultivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognitionen_IE
dc.typeArticleen_IE
dc.date.updated2016-10-19T09:33:19Z
dc.identifier.doi10.3390/molecules21050629
dc.local.publishedsourcehttp://dx.doi.org/10.3390/molecules21050629en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid11554405
dc.local.contactPaul Murphy, School Of Chemistry, Room 236, Arts/Science Building, Nui Galway. 2465 Email: paul.v.murphy@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland