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dc.contributor.authorVigliotti, A.
dc.contributor.authorRonan, William
dc.contributor.authorBaaijens, F.P.T.
dc.contributor.authorDeshpande, V.S.
dc.date.accessioned2016-08-09T13:42:51Z
dc.date.issued2015-09-04
dc.identifier.citationVigliotti, A., Ronan, W., Baaijens, F. P. T., & Deshpande, V. S. (2016). A thermodynamically motivated model for stress-fiber reorganization. Biomechanics and Modeling in Mechanobiology, 15(4), 761-789. doi: 10.1007/s10237-015-0722-9en_IE
dc.identifier.issn1617-7940
dc.identifier.urihttp://hdl.handle.net/10379/5934
dc.description.abstractWe present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These kinetics are motivated by considering the enthalpies of the actin/myosin functional units that constitute the stress fibers. The stress, strain and strain rate dependence of the stress-fiber dynamics are natural outcomes of the approach. The model is presented in a general 3D framework and includes the transport of the unbound stress-fiber proteins. Predictions of the model for a range of cyclic loadings are illustrated to rationalize hitherto apparently contrasting observations. These observations include: (1) For strain amplitudes around 10 % and cyclic frequencies of about 1 Hz, stress fibers align perpendicular to the straining direction in cells subjected to cyclic straining on a 2D substrate while the stress fibers align parallel with the straining direction in cells constrained in a 3D tissue. (2) At lower applied cyclic frequencies, stress fibers in cells on 2D substrates display no sensitivity to symmetric applied strain versus time waveforms but realign in response to applied loadings with a fast lengthening rate and slow shortening. (3) At very low applied cyclic frequencies (on the order of mHz) with symmetric strain versus time waveforms, cells on 2D substrates orient perpendicular to the direction of cyclic straining above a critical strain amplitude.en_IE
dc.description.sponsorshipA.V. and V.S.D. acknowledge the Royal Society for supporting A.V. through a Newton International Fellowship.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringer Verlagen_IE
dc.relation.ispartofBiomechanics and modeling in mechanobiologyen
dc.subjectMechano-sensitivityen_IE
dc.subjectActin/myosin contractilityen_IE
dc.subjectStress fibersen_IE
dc.subjectCytoskeletonen_IE
dc.subjectMechanical engineeringen_IE
dc.subjectBiomedical engineeringen_IE
dc.titleA thermodynamically motivated model for stress-fiber reorganizationen_IE
dc.typeArticleen_IE
dc.date.updated2016-07-29T14:58:04Z
dc.identifier.doi10.1007/s10237-015-0722-9
dc.local.publishedsourcehttp:/dx.doi.org/10.1007/s10237-015-0722-9en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2016-09-04
dc.internal.rssid11156645
dc.local.contactWilliam Ronan, Mechanical Engineering, School Of Engineering, Nui Galway. Email: william.ronan@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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