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dc.contributor.authorBurke, Nikita N.
dc.contributor.authorFinn, David P.
dc.contributor.authorRoche, Michelle
dc.date.accessioned2016-06-09T10:23:49Z
dc.date.available2016-06-09T10:23:49Z
dc.date.issued2015
dc.identifier.citationBurke N.N., Finn DP, Roche M (2015) 'Neuroinflammatory mechanisms linking Pain and Depression' In: Pain in Psychiatric Disorders: Mod Trends Pharmacopsychiatry. Switzerland : Karger.en_IE
dc.identifier.isbn978-3-318-05574-0
dc.identifier.urihttp://hdl.handle.net/10379/5872
dc.description.abstractDepression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either disorder alone. A number of neural substrates have been proposed to underlie this association; however, there has been increased interest and support for a role of neuroimmune and neuroinflammatory mechanisms as key players in this dyad. This chapter will provide an overview of the clinical and preclinical data supporting a role for neuroimmune alterations in depression-pain co-morbidity. We propose that such changes may impact on the functioning of key brain regions modulating emotional and nociceptive processing, thus resulting in the behavioural, psychological and physical symptoms observed in patients exhibiting depression and co-morbid pain.en_IE
dc.description.sponsorshipScience Foundation Ireland Research Frontiers Project (11/RFP/NES/3175), the Discipline of Physiology and a PhD Scholarship from the College of Medicine, National University of Irelanden_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherKargeren_IE
dc.relation.ispartofPain in Psychiatric Disorders: Mod Trends Pharmacopsychiatryen
dc.subjectDepressionen_IE
dc.subjectPainen_IE
dc.subjectNeuroinflammatory mechanismsen_IE
dc.subjectNeuroinflammationen_IE
dc.subjectPhysiologyen_IE
dc.titleNeuroinflammatory mechanisms linking pain and depressionen_IE
dc.typeBook chapteren_IE
dc.date.updated2016-05-23T13:42:47Z
dc.identifier.doi10.1159/000435931
dc.local.publishedsourcehttp://dx.doi.org/10.1159/000435931en_IE
dc.description.peer-reviewedPeer reviewed
dc.contributor.funder|~|1267880|~|
dc.internal.rssid10575295
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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