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dc.contributor.authorMcGrath, James
dc.contributor.authorAlexandrov, Sergey
dc.contributor.authorOwens, Peter
dc.contributor.authorSubhash, Hrebesh
dc.contributor.authorLeahy, Martin
dc.identifier.citationMcGrath, James, Alexandrov, Sergey, Owens, Peter, Subhash, Hrebesh, & Leahy, Martin. (2016). In vivo correlation mapping microscopy. Journal of Biomedical Optics, 21(4), 046004-046004. doi: 10.1117/1.JBO.21.4.046004en_IE
dc.description.abstractTo facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical coherence tomography (OCT), which extends the capabilities of OCT to microcirculation morphology imaging. This technique, known as correlation mapping optical coherence tomography, has been shown to extract parameters, such as capillary density and vessel diameter, and key clinical markers associated with early changes in microvascular diseases. However, OCT has limited spatial resolution in both the transverse and depth directions. Here, we extend this correlation mapping technique to other microscopy modalities, including confocal microscopy, and take advantage of the higher spatial resolution offered by these modalities. The technique is achieved as a processing step on microscopy images and does not require any modification to the microscope hardware. Results are presented which show that this correlation mapping microscopy technique can extend the capabilities of conventional microscopy to enable mapping of vascular networks in vivo with high spatial resolution in both the transverse and depth directions.en_IE
dc.description.sponsorshipNational Biophotonics Imaging Platform, Ireland, funded under the Higher Education Authority PRTLI Cycle 4, cofunded by the Irish government and the European Union—Investing in your future.en_IE
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en_IE
dc.relation.ispartofJournal Of Biomedical Opticsen
dc.subjectApplied physicsen_IE
dc.subjectCorrelation mappingen_IE
dc.subjectConfocal microscopyen_IE
dc.subjectWide field microscopyen_IE
dc.subjectNailfold capillaroscopyen_IE
dc.subjectBiomedical optical imagingen_IE
dc.titleIn vivo correlation mapping microscopyen_IE
dc.local.contactMartin Leahy, Applied Physics, School Of Physics, Room 122, Arts/Science Building, Nui Galway. 4260 Email:

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