Show simple item record

dc.contributor.authorBurke, Nikita N.
dc.contributor.authorGeoghegan, E.
dc.contributor.authorMoriarty, Orla
dc.contributor.authorFinn, David P.
dc.contributor.authorKerr, Daniel M.
dc.contributor.authorRoche, Michelle
dc.date.accessioned2016-05-23T10:53:17Z
dc.date.available2016-05-23T10:53:17Z
dc.date.issued2013-08-29
dc.identifier.citationBurke, NN,Geoghegan, E,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 12 :705-713.en_IE
dc.identifier.issn1601-183X
dc.identifier.urihttp://hdl.handle.net/10379/5826
dc.description.abstractThe association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive responding to mechanical and thermal stimuli prior to and following L5-L6 spinal nerve ligation (SNL), a model of neuropathic pain, in the olfactory bulbectomized (OB) rat model of depression. Associated changes in the expression of genes encoding for markers of glial activation and cytokines were subsequently examined in the amygdala, a key brain region for the modulation of emotion and pain. The OB rats exhibited mechanical and cold allodynia, but not heat hyperalgesia, when compared with sham-operated counterparts. Spinal nerve ligation induced characteristic mechanical and cold allodynia in the ipsilateral hindpaw of both sham and OB rats. The OB rats exhibited a reduced latency and number of responses to an innocuous cold stimulus following SNL, an effect positively correlated with interleukin (IL)-6 and IL-10 mRNA expression in the amygdala, respectively. Spinal nerve ligation reduced IL-6 and increased IL-10 expression in the amygdala of sham rats. The expression of CD11b (cluster of differentiation molecule 11b) and GFAP (glial fibrillary acidic protein), indicative of microglial and astrocyte activation, and IL-1 in the amygdala was enhanced in OB animals when compared with sham counterparts, an effect not observed following SNL. This study shows that neuropathic pain-related responding to an innocuous cold stimulus is altered in an animal model of depression, effects accompanied by changes in the expression of neuroinflammatory genes in the amygdala.en_IE
dc.description.sponsorshipThe authors would like to gratefully acknowledge funding received from the Discipline of Physiology and the Millennium Fund, National University of Ireland Galway. N.B. is a recipient of College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Doctoral Fellowship.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherWileyen_IE
dc.relation.ispartofGenes Brain And Behavioren
dc.subjectAmygdalaen_IE
dc.subjectAstrocyteen_IE
dc.subjectCytokineen_IE
dc.subjectDepressionen_IE
dc.subjectMicrogliaen_IE
dc.subjectNeuroinflammationen_IE
dc.subjectOlfactory bulbectomyen_IE
dc.subjectPainen_IE
dc.subjectPeripheral nerve injuryen_IE
dc.subjectSpinal nerve ligationen_IE
dc.subjectOlfactory bulbectomized ratsen_IE
dc.subjectMajor depressionen_IE
dc.subjectAntidepressant activityen_IE
dc.subjectBrain regionsen_IE
dc.subjectNerve injuryen_IE
dc.subjectMiceen_IE
dc.subjectActivationen_IE
dc.subjectHyperalgesiaen_IE
dc.subjectCytokinesen_IE
dc.subjectPhysiologyen_IE
dc.titleAltered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdalaen_IE
dc.typeArticleen_IE
dc.date.updated2016-04-22T15:38:59Z
dc.identifier.doiDOI 10.1111/gbb.12080
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/gbb.12080/fullen_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid5623446
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
nui.item.downloads272


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record