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dc.contributor.authorBurke, Nikita N.
dc.contributor.authorLlorente, Ricardo
dc.contributor.authorMarco, Eva M.
dc.contributor.authorTong, Kezanne
dc.contributor.authorFinn, David P.
dc.contributor.authorViveros, Maria-Paz
dc.contributor.authorRoche, Michelle
dc.identifier.citationBurke, NN,Llorente, R,Marco, EM,Tong, K,Finn, DP,Viveros, MP,Roche, M (2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'. Journal Of Pain, 14 :1173-1184.en_IE
dc.description.abstractEarly-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and following peripheral nerve injury (L5-L6 spinal nerve ligation [SNLD. Because neuroimmune signaling plays an important role in pain and affective disorders, associated alterations in glial and cytokine expression were assessed in key brain regions associated with emotional and nociceptive responding, the hippocampus and prefrontal cortex. MD female, but not male, rats exhibited thermal hypoalgesia and mechanical allodynia compared with control (non-MD) counterparts. SNL resulted in mechanical and cold allodynia in MD and control rats of both sexes. However, MD females exhibited enhanced SNL-induced allodynic responding compared with non-MD counterparts. Interleukin 6 (IL-6) expression was reduced in the prefrontal cortex of MD-SNL males when compared with non-SNL counterparts. Glial fibrillary acidic protein and IL-1 beta expression in the hippocampus of MD-SNL males was increased compared with non-MD controls. MD-SNL females exhibited reduced tumor necrosis factor alpha in the prefrontal cortex with a concomitant increase in IL-6 and tumor necrosis factor alpha expression in the hippocampus, compared with either MD or SNL alone. In conclusion, MD female, but not male, rats exhibit enhanced nociceptive responding following peripheral nerve injury, effects that may relate to the distinct neuroinflammatory profile observed in female versus male rats.Perspective: This study demonstrates that females rats exposed to early-life stress exhibit enhanced neuropathic pain responding, effects that are associated with alterations in neuroinflammatory mediators. Increased understanding of the interactions among early-life stress, gender, and pain may lead to the identification of novel therapeutic targets for the treatment of chronic pain disorders. (C) 2013 by the American Pain Societyen_IE
dc.relation.ispartofJournal Of Painen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectMaternal deprivationen_IE
dc.subjectSpinal nerve ligationen_IE
dc.subjectMechanical allodyniaen_IE
dc.subjectCold allodyniaen_IE
dc.subjectEarly life stressen_IE
dc.subjectFibrillary acidic proteinen_IE
dc.subjectPain like behavioren_IE
dc.subjectNeuropathic painen_IE
dc.subjectSeparation leadsen_IE
dc.subjectFemale ratsen_IE
dc.titleMaternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injuryen_IE
dc.identifier.doiDOI 10.1016/j.jpain.2013.05.003
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email:

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