Show simple item record

dc.contributor.authorRoche, Michelle
dc.contributor.authorCommons, Kathryn G.
dc.contributor.authorPeoples, Andrew
dc.contributor.authorValentino, Rita J.
dc.date.accessioned2016-05-05T12:49:44Z
dc.date.available2016-05-05T12:49:44Z
dc.date.issued2003-02-01
dc.identifier.citationRoche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997.en_IE
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/10379/5751
dc.description.abstractThe dorsal raphe nucleus (DR)–serotonin (5-HT) system has been implicated in depression and is dramatically affected by swim stress, an animal model with predictive value for antidepressants. Accumulating evidence implicates the stress-related neuropeptide corticotropin-releasing factor (CRF) in the effect of swim stress on this system. This study investigated neural circuits within the DR that are activated by swim stress as revealed by neuronal expression of the immediate early gene, c-fos. Swim stress increased c-fos expression in the dorsolateral subregion of the DR. The majority of c-fos-expressing neurons were doubly labeled for GABA (85 ± 5%), whereas relatively few were immunolabeled for 5-HT (4 ± 1%), glutamate (0.5 ± 0.3%) or calbindin (1.5 ± 0.3%). Dual immunohistochemical labeling revealed that c-fos-expressing neurons in the dorsolateral DR were enveloped by dense clusters of CRF-immunoreactive fibers and also contained immunolabeling for CRF receptor, suggesting that c-fos-expressing neurons in the DR were specifically targeted by CRF. Consistent with this, the CRF receptor 1 antagonist, antalarmin, prevented swim-stress-elicited c-fos expression in the dorsolateral DR. Together with previous findings that both swim stress and CRF decrease 5-HT release in certain forebrain regions, these results suggest that swim stress engages CRF inputs to GABA neurons in the dorsolateral DR that function to inhibit 5-HT neurons and 5-HT release in the forebrain. This circuitry may underlie some of the acute behavioral responses to swim stress as well as the neuronal plasticity involved in long-term behavioral changes produced by this stress.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSociety for Neuroscienceen_IE
dc.relation.ispartofJournal of Neuroscienceen
dc.subjectDorsal raphe nucleusen_IE
dc.subjectSerotoninen_IE
dc.subjectCorticotropin-releasing factoren_IE
dc.subjectGABAen_IE
dc.subjectc- fosen_IE
dc.subjectAntalarminen_IE
dc.subjectSwim stressen_IE
dc.subjectPhysiologyen_IE
dc.titleCircuitry underlying regulation of the serotonergic system by swim stressen_IE
dc.typeArticleen_IE
dc.date.updated2016-04-22T15:45:25Z
dc.local.publishedsourcehttp://www.jneurosci.org/content/23/3/970.shorten_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid1167539
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
nui.item.downloads226


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record