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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ...
Anandamide modulation of endotoxin-induced inflammation
(OMICS International, 2013-12-20)
The endocannabinoid system is comprised of the CB1
and CB2
receptors, the naturally occurring endogenous ligands, anandamide
(AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes
involved in their synthesis and ...
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
(Elsevier, 2015-03-17)
Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ...