Browsing Physiology (Scholarly Articles) by Author "Brinjikji, Waleed"

Now showing items 1-9 of 9

    • Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report 

      Fitzgerald, Seán; Rizvi, Asim; Dai, Daying; Williamson, Eric E.; Lanzino, Giuseppe; Doyle, Karen M.; Kallmes, David F.; Brinjikji, Waleed (SAGE Publications, 2018-11-14)
      Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ...

    • Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Molina, Sara; Okolo, Adaobi; Douglas, Andrew; Jabrah, Duaa; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; Alderson, Jack; O’Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Elsevier, 2020-11-24)
      Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ...

    • Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing 

      Fitzgerald, Seán; Liu, Yang; Dai, Daying; Mereuta, Oana Madalina; Abbasi, Mehdi; Larco, JL Arturo; Douglas, Andrew; Kallmes, David; Savastano, Luis; Doyle, Karen M.; Brinjikji, Waleed (American Society of Neuroradiology, 2021-04-08)
      BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot analogs for in vitro endovascular device testing using animal blood of various species. Blood components vary greatly among species; therefore, ...

    • Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Murphree Jr, Dennis H.; Pandit, Abhay; Douglas, Andrew; Rizvi, Asim; Kadirvel, Ramanathan; Gilvarry, Michael; McCarthy, Ray; Stritt, Manuel; Gounis, Matthew J.; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Public Library of Science, 2019-12-05)
      Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ...

    • Per pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted-clot-area and histological composition 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Jabrah, Duaa; Okolo, Adaobi; Douglas, Andrew; Molina Gil, Sara; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Dunker, Dennis; Nordanstig, Annika; Ceder, Erik; Redfors, Petra; Jood, Katarina; Dehlfors, Niclas; Magoufis, Georgios; Tsivgoulis, Georgios; Brinjikji, Waleed; Kallmes, David F.; Hare, Alan; Power, Sarah; Brennan, Paul; Alderson, Jack; Nagy, András; Vadász, Ágnes; Psychogios, Klearchos; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2020-12-09)
      Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic ...

    • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Douglas, Andrew; Kadirvel, Ramanathan; Gounis, Matthew J.; Chueh, Juyu; Puri, Ajit S.; Layton, Kennith F.; Thacker, Ike C.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Almekhlafi, Mohammed A.; Demchuk, Andrew M.; Nogueira, Raul G.; Pereira, Vitor M.; Kvamme, Peter; Kayan, Yasha; Delgado Almandoz, Josser E.; Yoo, Albert J.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2019-04-05)
      Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ...

    • Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes 

      Douglas, Andrew; Fitzgerald, Seán; Mereuta, Oana Madalina; Rossi, Rosanna; O'Leary, Sean; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Holmegaard, Lukas; Abrahamsson, Margareta; Jerndal, Mikael; Dehlfors, Niclas; Brennan, Paul; Power, Sarah; O'Hare, Alan; Griffin, Emma; Kallmes, David F.; Brinjikji, Waleed; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2019-11-04)
      Background and aims Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS ...

    • Platelet-rich emboli in cerebral large vessel occlusion are associated with a large artery atherosclerosis source 

      Fitzgerald, Seán; Dai, Daying; Wang, Shunli; Douglas, Andrew; Kadirvel, Ramanathan; Layton, Kennith F.; Thacker, Ike C.; Gounis, Matthew J.; Chueh, Ju-Yu; Puri, Ajit S.; Almekhlafi, Mohammed; Demchuk, Andrew M.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Yoo, Albert J.; Kvamme, Peter; Pereira, Vitor M.; Kayan, Yasha; Delgado Almandoz, Josser E.; Nogueira, Raul G.; Rabinstein, Alejandro A.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (American Heart Association, 2019-05-29)
      Background and Purpose— Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and ...

    • Studying stroke thrombus composition after thrombectomy: What can we learn? 

      Staessens, Senna; François, Olivier; Brinjikji, Waleed; Doyle, Karen M.; Vanacker, Peter; Andersson, Tommy; De Meyer, Simon F. (Lippincott, Williams & Wilkins, 2021-09-14)
      The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity ...