Browsing Physiology (Scholarly Articles) by Title
Now showing items 30-46 of 46
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Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
(Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ... -
A multi-stage human factors and comfort assessment of instrumented insoles designed for use in a connected health infrastructure
(MDPI, 2015-12-16)Wearable electronics are gaining widespread use as enabling technologies, monitoring human physical activity and behavior as part of connected health infrastructures. Attention to human factors and comfort of these devices ... -
Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots
(Public Library of Science, 2019-12-05)Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ... -
The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse.
(Nature Research, 2019-11-04)The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis. Given ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid
(Elsevier, 2016-08-31)Autism spectrum disorders are a group of neurodevelopmental disorders characterised by impaired social interaction, deficits in communication and repetitive stereotyped behaviours. The endocannabinoid system plays an ... -
Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes
(BMJ Publishing Group, 2019-11-04)Background and aims Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS ... -
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
(Bentham Science Publishers, 2007)The endogenous polyamines (spermine, spermidine, and putrescine) are present at relatively high concentrations in the mammalian brain and play crucial roles in a variety of aspects of cell functioning. Stroke is the third ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
(Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
(Wiley, 2013-02-21)Background and Aim TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
(Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ... -
Storage of blood clots for histological analysis: How long is too long in saline and paraformaldehyde?
(Universidad de Murcia, 2019)To investigate the composition of blood clots following mechanical thrombectomy, it is essential to ensure optimum storage for highest quality histological and immunofluorescence analysis. We investigated for how long clots ... -
Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
(BMC (part of Springer Nature), 2018-04-10)Background Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ... -
These shoes are made for walking: sensitivity performance evaluation of commercial activity monitors under the expected conditions and circumstances required to achieve the international daily step goal of 10,000 steps
(Public Library of Science, 2016-05-11)IntroductionPhysical activity is a vitally important part of a healthy lifestyle, and is of major benefit to both physical and mental health. A daily step count of 10,000 steps is recommended globally to achieve an appropriate ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
(Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ... -
Ulk4 regulates GABAergic signaling and anxiety-related behavior
(Springer Nature, 2018-02-02)Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ... -
When a step is not a step! Specificity analysis of five physical activity monitors
(Public Library of Science, 2017-01-13)IntroductionPhysical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important ...