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dc.contributor.authorAlexandrov, Sergey
dc.contributor.authorSubhash, Hrebesh M.
dc.contributor.authorZam, Azhar
dc.contributor.authorLeahy, Martin
dc.date.accessioned2016-02-04T09:57:42Z
dc.date.available2016-02-04T09:57:42Z
dc.date.issued2014
dc.identifier.citationS. Alexandrov, H. M. Subhash, A. Zam and M. Leahy (2014) 'Nano-sensitive optical coherence tomography'. Nanoscale, 6 :3545-3549.en_IE
dc.identifier.issn2040-3372
dc.identifier.urihttp://hdl.handle.net/10379/5526
dc.description.abstractDepth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and healthcare diagnostics arenas. Here we experimentally demonstrate a novel label-free depth resolved sensing technique based on optical coherence tomography (OCT) to detect structural changes at the nanoscale. Structural components of the 3D object, spectrally encoded in the remitted light, are transformed from the Fourier domain into each voxel of the 3D OCT image without compromising sensitivity. Spatial distribution of the nanoscale structural changes in the depth direction is visualized in just a single OCT scan. This label free approach provides new possibilities for depth resolved study of pathogenic and physiologically relevant molecules in the body with high sensitivity and specificity. It offers a powerful opportunity for early diagnosis and treatment of diseases. Experimental results show the ability of the approach to differentiate structural changes of 30 nm in nanosphere aggregates, located at different depths, from a single OCT scan, and structural changes less than 30 nm in time from two OCT scans. Application for visualization of the structure of human skin in vivo is also demonstrated.en_IE
dc.formatpdfen_IE
dc.language.isoenen_IE
dc.publisherRoyal Society of Chemistryen_IE
dc.relation.ispartofNanoscaleen
dc.subjectPhysicsen_IE
dc.subjectTomographyen_IE
dc.subjectOptical coherence tomographyen_IE
dc.subjectNanoscaleen_IE
dc.subjectNano-sensitiveen_IE
dc.titleNano-sensitive optical coherence tomographyen_IE
dc.typeArticleen_IE
dc.date.updated2016-02-02T10:13:37Z
dc.identifier.doi10.1039/C3NR06132A
dc.local.publishedsourcehttp://pubs.rsc.org/en/Content/ArticleLanding/2014/NR/c3nr06132a#!divAbstracten_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid8146135
dc.local.contactSergey Alexandrov, School Of Physics, Nui Galway. Email: sergey.alexandrov@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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