Show simple item record

dc.contributor.authorParmenter, Christopher D. J.
dc.contributor.authorChen, Rong
dc.contributor.authorCheung, David L.
dc.contributor.authorBon, Stefan A. F.
dc.date.accessioned2016-01-25T13:40:49Z
dc.date.available2016-01-25T13:40:49Z
dc.date.issued2013
dc.identifier.citationParmenter, Christopher D. J.; Chen, Rong; Cheung, David L.; Bon, Stefan A. F. (2013) 'Morphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in water'. Soft Matter, 9 (29):6890-6896.en_IE
dc.identifier.issn1744-6848
dc.identifier.urihttp://hdl.handle.net/10379/5490
dc.description.abstractWe show that when unilamellar polymer vesicles dispersed in water made from a blockcopolymer, in this case poly((ethylene oxide)45-block-(methyl methacrylate)164), poly((ethylene oxide)45-block-(methyl methacrylate)170), or poly(n-butyl methacrylate)81-block-(2-(dimethylamino)ethyl methacrylate)20, are exposed to small hydrophobic molecules, here methyl methacrylate as well as n-butyl methacrylate, they can undergo morphological transitions. Upon swelling, the polymersomes lose their original simple bilayer morphology and transform into more complex coil-like and patchy colloidal structures, as investigated experimentally by cryogenic electron microscopy (cryo-EM). Dissipative particle dynamics (DPD) simulations on a model flat bilayer indeed show that transitions can occur upon bilayer swelling, which is accompanied by a change in the mechanical bilayer properties. The transition involves the formation of water pockets in the interior regions of the bilayer. Co-existence of the various morphologies in the experiments suggests an activation barrier towards morphological changes and a possibility of multiple meta-stable states. The latter indeed is supported by the existence of multiple minima in the surface tension as a function of bilayer area, as found in the simulations.en_IE
dc.description.sponsorshipEPSRC doctoral training account studentship (CDJP), Warwick Institute of Advanced Study (IAS) for an incubation award (DLC), and the Leverhulme trust for an early career fellowship (DLC).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherRoyal Society of Chemistryen_IE
dc.relation.ispartofSoft Matteren
dc.subjectMorphological transitionsen_IE
dc.subjectPolymer vesiclesen_IE
dc.subjectBilayer swellingen_IE
dc.subjectHydrophobic moleculesen_IE
dc.subjectChemistryen_IE
dc.titleMorphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in wateren_IE
dc.typeArticleen_IE
dc.date.updated2015-12-17T22:16:15Z
dc.identifier.doi10.1039/C3SM50184A
dc.local.publishedsourcehttp://pubs.rsc.org/en/Content/ArticleLanding/2013/SM/c3sm50184a#!divAbstracten_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid8559072
dc.local.contactDavid Cheung, School Of Chemistry, Nuig. Email: david.cheung@nuigalway.ie
dc.local.copyrightcheckedNo
nui.item.downloads68


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record