Browsing Biochemistry (Scholarly Articles) by Author "Onwubiko, Nichodemus O."
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Alkoxyalkyl esters of nucleotide analogs inhibit polyomavirus DNA replication and large T antigen activities
Onwubiko, Nichodemus O.; Diaz, Suraya; Krecmerova, Marcela; Nasheuer, Heinz-Peter (American Society for Microbiology Journals, 2020-12-07)Polyomavirus-related infections are ubiqutious in immunocompromised individuals and in some cases are intractable and fatal. Due to lack of approved drugs to treat polyomavirus infections, cidofovir, a phosphonate nucleotide ... -
SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation
Onwubiko, Nichodemus O.; Scheffel, Felicia; Tessmer, Ingrid; Nasheuer, Heinz-Peter (Wiley Open Access and Federation of European Biochemical Societies, 2022-01-24)The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase ¿-primase (Pol-prim). Since cellular ... -
SV40 T antigen interactions with ssDNA and replication protein A: a regulatory role of T antigen monomers in lagging strand DNA replication
Onwubiko, Nichodemus O.; Borst, Angela; Diaz, Suraya A.; Passkowski, Katharina; Scheffel, Felicia; Tessmer, Ingrid; Nasheuer, Heinz-Peter (Oxford University Press (OUP), 2020-03-04)DNA replication is a central process in all living organisms. Polyomavirus DNA replication serves as a model system for eukaryotic DNA replication and has considerably contributed to our understanding of basic replication ...