Now showing items 21-26 of 26

    • The integrated stress response 

      Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO Press, 2016-09-14)
      In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ...
    • Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity 

      Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)
      Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ...
    • RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells 

      Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)
      Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ...
    • ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+ 

      Bandla, Sravanthi; Diaz, Suraya; Nasheuer, Heinz-Peter; FitzGerald, Una (Wiley Open Access, 2019-08-29)
      B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone normally found in the ER lumen. However, BiP also has other extracellular and intracellular functions. As it is unclear whether ...
    • RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster 

      Mills, Wilbur Kyle; Lee, Yuh Chwen G.; Kochendoerfer, Antje M.; Dunleavy, Elaine M.; Karpen, Gary H. (eLife Sciences Publications, 2019-11-05)
      Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that ...
    • Determination of the number of RAD51 molecules in different human cell lines 

      Foertsch, Franziska; Kache, Tom; Drube, Sebastian; Biskup, Christoph; Nasheuer, Heinz-Peter; Melle, Christian (Taylor & Francis, 2019-11-15)
      Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous ...