Browsing CÚRAM - Centre for Research in Medical Devices (Scholarly Articles) by Title
Now showing items 18-37 of 39
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Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus
(Nature Publishing Group:, 2015-10-22)Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the ... -
A glycotherapeutic approach to functionalize biomaterials-based systems
(Wiley, 2020-03-18)In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery ... -
High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
(BMJ Publishing Group, 2020-12-23)Background: Characterization of acute ischemic stroke (AIS) clots has typically focused on two dimensional histological analysis of the thrombus. The three dimensional (3D) architecture and distribution of components ... -
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy
(BMJ Publishing Group, 2021-05-11)Background Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following ... -
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ... -
Hypoxia preconditioning of bone marrow mesenchymal stem cells before implantation in orthopaedics
(Lippincott, Williams & Wilkins, 2019-12-01)[No abstract available] -
In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations
(Elsevier, 2020-04-08)Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen ... -
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ... -
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
(Springer Verlag, 2018-07-31)The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ... -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
Low resistance, highly corrugated structures based on poly(3,4-ethylenedioxythiophene) doped with a d-glucopyranoside-derived ionic liquid
(Elsevier, 2019-12-02)Conjugated polymers have gained significant interest as highly conducting organic materials with versatile surface morphology. In this study, we demonstrate that the electrodeposition of poly(3,4-ethylenedioxythiophene), ... -
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Microwave ablation antenna for functional adenomas in the adrenal gland
(IEEE, 2020-03-02)Microwave thermal ablation has been thoroughly investigated in the last decades. However, new challenges for this technology are nowadays represented by specific applications. The present work investigates a promising ... -
Preparation and characterization of tissue surrogates rich in extracellular matrix using the principles of macromolecular crowding
(Humana Press, 2019-03)Tissue engineering by self-assembly allows for the fabrication of living tissue surrogates by taking advantage of the cell's inherent ability to produce and deposit tissue-specific extracellular matrix. However, the long ... -
Recent advances in host–guest self‐assembled cyclodextrin carriers: Implications for responsive drug delivery and biomedical engineering
(Wiley, 2020-02-05)This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical ... -
Self-supporting carbon nanotube films as flexible neural interfaces
(Elsevier, 2018-10-26)Advances in neural interface technologies have sought to identify electroactive materials that are able to translate neural depolarisation events into digital signals or modulate neural firing through ionic or electrical ... -
The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents
(IOP Publishing, 2020-02-26)Cellular therapies play an important role in tendon tissue engineering, with tenocytes being the most prominent and potent cell population available. However, for the development of a rich extracellular matrix tenocyte-assembled ... -
The synergistic effects of gold particles and dexamethasone on the electrochemical and biological performance of PEDOT neural interfaces
(MDPI, 2019-01-05)Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim ... -
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
(Nature Publishing Group, 2017-10-13)Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these ... -
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
(De Gruyter, 2019-12-09)The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection ...