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dc.contributor.authorZhou, Jian
dc.contributor.authorReidy, Mairead
dc.contributor.authorO'Reilly, Ciaran
dc.contributor.authorJarikote, Dilip V.
dc.contributor.authorNegi, Arvind
dc.contributor.authorSamali, Afshin
dc.contributor.authorSzegezdi, Eva
dc.contributor.authorMurphy, Paul V.
dc.date.accessioned2015-12-10T11:28:15Z
dc.date.issued2015-03-16
dc.identifier.citationZhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675.en_IE
dc.identifier.issn1523-7052
dc.identifier.urihttp://hdl.handle.net/10379/5380
dc.description.abstractA build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.en_IE
dc.description.sponsorshipScience Foundation Ireland (Grant Nos. 12/TIDA/B2371, 06/CHEO32, 09/SIRG/B1575) and the European Research Agency (Marie Curie EIF Grant No. 220948 to DVJ)en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherAmerican Chemical Societyen_IE
dc.relation.ispartofOrganic Lettersen
dc.subjectDiversity-oriented synthesisen_IE
dc.subjectTerminal alkynesen_IE
dc.subjectScaffoldsen_IE
dc.subjectChemistryen_IE
dc.subjectMetathesisen_IE
dc.subjectPrecursorsen_IE
dc.subjectStrategyen_IE
dc.subjectLectinsen_IE
dc.subjectAzidesen_IE
dc.subjectProteinen_IE
dc.subjectChemistryen_IE
dc.titleDecorated macrocycles via ring-closing double-reductive amination. Identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptoren_IE
dc.typeArticleen_IE
dc.date.updated2015-11-30T12:01:28Z
dc.identifier.doi10.1021/acs.orglett.5b00404
dc.local.publishedsourcehttp://dx.doi.org/10.1021/acs.orglett.5b00404en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2016-03-16
dc.internal.rssid8734390
dc.local.contactPaul Murphy, School Of Chemistry, Room 236, Arts/Science Building, Nui Galway. 2465 Email: paul.v.murphy@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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