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dc.contributor.advisorMcNamara, Laoise
dc.contributor.authorGunning, Paul
dc.description.abstractPatients with calcific aortic valve stenosis present with calcium deposits on the aortic valve, which can result in non-circular and distorted expansion of self-expanding Transcatheter Aortic Valve Replacements. The effect of stent distortion on the fluid and shear environments downstream of the valve and the deformation of the leaflets of the prosthesis are not yet fully understood. Therefore the objectives of this thesis are to investigate the impact of non-circular stent deployment on: (1) the fluid mechanics and hemolytic potential of the device; (2) leaflet mechanics and deformation and (3) the development of a computational finite element framework of the deployment of a self-expanding Transcatheter Aortic Valve Replacement in a patient-specific aortic root anatomy. The results of this thesis demonstrate that: (1) eccentric stent distortion alters the fluid and shear environments downstream of the valve; (2) eccentric stent distortion causes deleterious bending of the leaflet causing an increase in peak strains in the vicinity of the leaflet commissures; (3) stent deployment asymmetry is dependent upon location and distribution of calcium deposits on the aortic valve leaflets and (4) preoperative planning of stent orientation within the aortic valve has the potential to minimise the impact of the distorted stent on the deformation of leaflets of the prosthesis. The results of this thesis elucidate the effect of non-circular stent deployment on the coupled fluid and leaflet mechanics of Transcatheter Aortic Valve Replacements deployed in calcified aortic valves in vivo and provide a novel understanding of the biomechanical tissue-stent interaction during self-expanding stent deployment in patient-specific anatomies.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectDistorted Stenten_US
dc.subjectTranscatheter aortic valveen_US
dc.subjectFinite elementen_US
dc.subjectParticle image velocimetryen_US
dc.subjectDual camera stereophotogrammetryen_US
dc.subjectDigital image correlationen_US
dc.subjectBiomedical Engineeringen_US
dc.titleExperimental and computational investigation of the impact of distorted stent expansion on the performance of transcatheter aortic valve replacementsen_US
dc.contributor.funderCollege of Engineering and Informaticsen_US
dc.local.noteTranscatheter Aortic Valve Replacement is a percutaneous alternative to open heart surgical valve replacement, which provides treatment of patients for whom conventional surgery is deemed unfeasible. Patients with aortic stenosis present with large calcium deposits on the native aortic valve which can cause non-circular expansion of the valve stent. It is not yet known whether distorted stent geometries can alter leaflet mechanics sufficiently to cause non-physiological flow downstream of the valve or cause altered leaflet loading The objective of this research is to develop computational and experimental studies to investigate the impact of non-circular stent deployment on leaflet deformation and blood flow through the valve.en_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland