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dc.contributor.authorCannon, Dara
dc.identifier.citationDara M. Cannon, Jacqueline M. Klaver, Summer A. Klug, Paul J. Carlson, David A. Luckenbaugh, Masanori Ichise and Wayne C. Drevets (2013). Gender-specific abnormalities in the serotonin transporter system in panic disorder. The International Journal of Neuropsychopharmacology, 16, pp 733-743. doi:10.1017/S1461145712000776.en_US
dc.description.abstractThe central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover, reduced pre- and post-synaptic 5-HT(1A-)receptor sensitivity and binding and clinical improvement during administration of agents that enhance serotonergic transmission. Polymorphisms in genes that putatively influence serotonergic neurotransmission increase the vulnerability for developing PD specifically in males. We tested the hypotheses that serotonin transporter (5-HTT) binding is elevated in PD subjects vs. healthy controls in regions where in vivo evidence exists for both elevated 5-HTT and 5-HT1A receptor levels in PD and investigated whether the extent of this difference depends upon gender. Volunteers were out-patients with current PD (n=24) and healthy controls (n=24). The non-displaceable component of 5-HTT binding-potential (BPND) was measured using positron emission tomography and the 5-HTT selective radioligand, [C-11]DASB. PD severity was assessed using the PD Severity Scale. The 5-HTT-BPND was increased in males with PD relative to male controls in the anterior cingulate cortex (F=8.96, p(FDR)=0.01) and midbrain (F=5.09, p(FDR)=0.03). In contrast, BPND did not differ between females with PD and female controls in any region examined. The finding that 5-HTT-binding is elevated in males but not in females with PD converges with other evidence suggesting that dysfunction within the central serotonergic system exists in PD, and also indicates that such abnormalities are influenced by gender. These findings conceivably may reflect a sexual dimorphism that underlies the greater efficacy of serotonin reuptake inhibitor treatment in females vs. males with PD.en_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofInternational Journal Of Neuropsychopharmacologyen
dc.subjectCingulate cortexen_US
dc.subjectBipolar Disorderen_US
dc.subjectAnxiety sensitivityen_US
dc.subjectReuptake inhibitorsen_US
dc.subjectPositron emission tomographyen_US
dc.subjectDepressive disorderen_US
dc.titleGender-specific abnormalities in the serotonin transporter system in panic disorderen_US
dc.local.contactDara Cannon, Anatomy, Nui, Galway. 5692 Email:

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