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dc.contributor.authorSavitz, J,Nugent, AC,Cannon, DM,Carlson, PJ,Davis, R,Neumeister, A,Rallis-Frutos, D,Fromm, S,Herscovitch, P,Drevets, WC
dc.date.accessioned2015-07-22T12:07:43Z
dc.date.available2015-07-22T12:07:43Z
dc.date.issued2012
dc.identifier.citationSavitz, J,Nugent, AC,Cannon, DM,Carlson, PJ,Davis, R,Neumeister, A,Rallis-Frutos, D,Fromm, S,Herscovitch, P,Drevets, WC (2012) 'Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder'. Scientific Reports, 2 .en_US
dc.identifier.urihttp://hdl.handle.net/10379/5091
dc.description.abstractIndividuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [O-15]-H2O positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDDpatients and 62 HCs were scanned following arterial cannulation and 15MDDpatients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reportsen
dc.subjectMedial prefrontal cortexen_US
dc.subjectPositron-emission-tomographyen_US
dc.subjectCortisol-levelsen_US
dc.subjectAnterior cingulate cortexen_US
dc.subjectDefault-mode networken_US
dc.subjectPainful stimulationen_US
dc.subjectHippocampal volumeen_US
dc.subjectGlucose-metabolismen_US
dc.subjectBipolar disorderen_US
dc.subjectBrain activationen_US
dc.titleEffects of arterial cannulation stress on regional cerebral blood flow in major depressive disorderen_US
dc.typeArticleen_US
dc.date.updated2015-03-21T00:02:10Z
dc.identifier.doiARTN 308
dc.local.publishedsourcehttp://www.nature.com/articles/srep00308en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid2195981
dc.local.contactDara Cannon, Anatomy, Nui, Galway. 5692 Email: dara.cannon@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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