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dc.contributor.advisorO'Donnell, Martin
dc.contributor.authorSmyth, Coleman Andrew
dc.description.abstractChronic Kidney Disease (defined by decreased glomerular filtration rate and proteinuria) is associated with significant morbidity, increased cardiovascular risk and premature mortality. Advanced chronic kidney disease, including end-stage renal disease, places a significant burden on patients and healthcare systems. There is a need to identify approaches to reduce the global burden of CKD, as prevalence is rising. Dietary modification may be one such approach. Employing multiple research methodologies and statistical approaches, this PhD thesis addresses the association between diet and both surrogate and clinical renal outcomes. In particular, I focus on the following areas: (i) the association between dietary sodium intake and renal outcomes (systematic review, two prospective cohort studies and the development of a protocol for a randomised controlled trial); (ii) the association between dietary potassium intake and renal outcomes (two prospective cohort studies); (iii) the association between diet quality and renal outcomes (one prospective cohort study); (iv) the association between chronic kidney disease and functional impairment, a patient important outcome (cross-sectional study). The work presented in this thesis explores these associations in different populations (i) a high cardiovascular risk population (ONTARGET/TRANSCEND cohorts) and (ii) the general population of older adults (NIH-AARP Diet and Health Study and the CLARITY Study). The content of this thesis provides novel observational evidence on the association between diet and renal outcomes, including two of the largest prospective cohort studies reported in this area. My observational research work identified considerable uncertainty about the benefits of low sodium intake, which lead to the development of a randomised controlled trial in patients with chronic kidney disease, which will provide key data on the relationship between sodium intake and renal outcomes in patients with CKD.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectKidney diseaseen_US
dc.titleDiet and renal outcomesen_US
dc.contributor.funderHealth Research Board, Irelanden_US
dc.local.noteKidney disease is linked with higher risks of death, heart disease and hospitalisation, both in Ireland and on a global level. There is a need to identify ways to reduce kidney disease. In this PhD thesis I explore the link between diet quality and dietary sodium (salt intake) and kidney disease. The work in this PhD suggests that a healthy diet (based on diet quality scores) may reduce the risk of future kidney disease.en_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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