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dc.contributor.authorMoriarty, O,Roche, M,McGuire, BE,Finn, DP
dc.date.accessioned2015-03-13T11:49:05Z
dc.date.available2015-03-13T11:49:05Z
dc.date.issued2012
dc.identifier.citationMoriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8.en
dc.identifier.urihttp://hdl.handle.net/10379/4888
dc.description.abstractChronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance paradigms traditionally use foot-shock to induce context-conditioned avoidance and may be unsuitable for use in animal models of chronic pain, which are commonly associated with hypersensitivity of the hind-paws. The aim of the present study was to develop and validate a novel passive-avoidance paradigm in rats, employing air-puff as the aversive stimulus, and to use this paradigm to assess aversive learning and memory in rat models of chronic inflammatory and neuropathic pain. Air-puff exposure produced a significant passive-avoidance and this response was attenuated following administration of scopolamine. Nerve-ligated rats and rats injected with complete Freund's adjuvant developed allodynia and hyperalgesia. Air-puff produced a significant passive-avoidance response in both chronic pain models. However, there was no difference in the response between either model and its respective control group. Thus, air-puff can be used as an alternative to foot-shock to induce a passive-avoidance response. The data generated using this model suggest that aversive learning and memory remain intact in the rat spinal nerve ligation and complete Freund's adjuvant models of chronic neuropathic and inflammatory pain, respectively. (C) 2011 Elsevier B.V. All rights reserved.en
dc.language.isoen
dc.relation.ispartofJournal Of Neuroscience Methodsen
dc.subjectPassive avoidance
dc.subjectConditioned aversion
dc.subjectLearning
dc.subjectMemory
dc.subjectChronic pain
dc.subjectPOSTTRAUMATIC-STRESS-DISORDER
dc.subjectNEUROPATHIC PAIN
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectINFLAMMATORY PAIN
dc.subjectDECISION-MAKING
dc.subjectATTENTION
dc.subjectDEFICITS
dc.subjectPERCEPTION
dc.subjectDEPRESSION
dc.subjectRETRIEVAL
dc.titleValidation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic painen
dc.typeArticle
dc.date.updated2013-01-09T15:12:06Z
dc.identifier.doiDOI 10.1016/j.jneumeth.2011.10.024
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid2196598
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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