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dc.contributor.authorMeere, Martin G.
dc.date.accessioned2015-02-03T13:08:12Z
dc.date.available2015-02-03T13:08:12Z
dc.date.issued2015-01-09
dc.identifier.citationTUOI T. N. VO, M.G. MEERE (2015) 'A mathematical model for the release of peptide-binding drugs from affinity hydrogels'. Cellular and Molecular Bioengineering, .en_US
dc.identifier.issn1865-5025
dc.identifier.urihttp://hdl.handle.net/10379/4838
dc.descriptionJournal articleen_US
dc.description.abstractA mathematical model for the release of peptide-binding drugs from affinity hydrogels is analyzed in detail. The model is not specific to any particular peptide/drug/gel system, and can describe drug release from a large class of affinity systems. In many cases, it is shown that the model can be reduced to a coupled pair of nonlinear partial differential equations for the total drug and peptide. Quantitative information relating the rate of drug release to the values of the model parameters is presented. Numerical solutions are displayed that illustrate the rich variety of release behaviors the system is capable of exhibiting. Theoretical release profiles generated by the model are compared with experimental release data from three different studies, and good agreement is found. The development of reliable mathematical models for affinity hydrogels will provide useful design tools for these systems.en_US
dc.description.sponsorshipScience Foundation Ireland (SFI) - Investigator Award 12/IA/1683en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherPalgraveen_US
dc.relation.ispartofCellular and Molecular Bioengineeringen
dc.subjectAffinity hydrogelen_US
dc.subjectPeptide-binding drugen_US
dc.subjectMathematical modelen_US
dc.titleA mathematical model for the release of peptide-binding drugs from affinity hydrogelsen_US
dc.typeArticleen_US
dc.date.updated2015-02-03T09:38:01Z
dc.identifier.doi10.1007/s12195-014-0375-2
dc.local.publishedsourcehttp://dx.doi.org/10.1007/s12195-014-0375-2en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|SFI|~|
dc.internal.rssid8171566
dc.local.contactMartin Meere, Dept. Of Mathematical Physics, Room C120, Áras De Brún, Nui Galway. 3087 Email: martin.meere@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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