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dc.contributor.authorYan, Dandan
dc.contributor.authorMurphy, Paul V.
dc.date.accessioned2014-04-08T11:28:12Z
dc.date.available2014-04-08T11:28:12Z
dc.date.issued2012-07-27
dc.identifier.citationYan D, Naughton J, Clyne M, Murphy PV (2012) 'Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori'. Carbohydrate research, 360 :1-7.en_US
dc.identifier.issn0008-6215
dc.identifier.urihttp://hdl.handle.net/10379/4278
dc.descriptionJournal articleen_US
dc.description.abstractThe Cu(I) catalysed cycloaddition reaction of azides and alkynes has been used to generate a series of divalent GlcNAc clusters with both α and β configurations. These glycoclusters can be considered as potential mimetics of an anti Helicobacter pylori hexasaccharide as they present two GlcNAc residues grafted onto a core scaffold. Two bivalent compounds based on α-O-GlcNAc were identified that selectively reduced the viability of H. pylori. These compounds showed activity towards different strains of H. pylori (Pu4 vs P12). The activity of the oligosaccharide mimetics is speculated to be due to the GlcNAc residues being able to adopt spatial arrangements accessible to the anti H. pylori hexasaccharide which may be important for activity.en_US
dc.description.sponsorshipScience Foundation Ireland (08/SRC/B1393); IRCSETen_US
dc.formatapplication/MSWorden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCarbohydrate researchen
dc.subjectGlycoclustersen_US
dc.subjectGlcNAcen_US
dc.subjectGlycomimeticsen_US
dc.subjectHelicobacter pylorien_US
dc.subjectBactericidalen_US
dc.subjectAntibioticen_US
dc.titleSynthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori.en_US
dc.typeArticleen_US
dc.date.updated2014-04-04T11:51:32Z
dc.identifier.doi10.1016/j.carres.2012.07.011
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.carres.2012.07.011en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid5950707
dc.local.contactPaul Murphy, School Of Chemistry, Room 236, Arts/Science Building, Nui Galway. 2465 Email: paul.v.murphy@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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