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dc.contributor.authorRonan, William
dc.contributor.authorMcGarry, Patrick
dc.date.accessioned2014-01-31T14:35:14Z
dc.date.available2014-01-31T14:35:14Z
dc.date.issued2013-09-20
dc.identifier.citationRonan, W,Pathak, A,Deshpande, VS,McMeeking, RM,McGarry, JP (2013) 'Simulation of the Mechanical Response of Cells on Micropost Substrates'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 135 .en_US
dc.identifier.issn0148-0731
dc.identifier.urihttp://hdl.handle.net/10379/4118
dc.descriptionJournal articleen_US
dc.description.abstractExperimental studies where cells are seeded on micropost arrays in order to quantify their contractile behavior are becoming increasingly common. Interpretation of the data generated by this experimental technique is difficult, due to the complexity of the processes underlying cellular contractility and mechanotransduction. In the current study, a coupled framework that considers strain rate dependent contractility and remodeling of the cytoskeleton is used in tandem with a thermodynamic model of tension dependent focal adhesion formation to investigate the biomechanical response of cells adhered to micropost arrays. Computational investigations of the following experimental studies are presented: cell behavior on different sized arrays with a range of post stiffness; stress fiber and focal adhesion formation in irregularly shaped cells; the response of cells to deformations applied locally to individual posts; and the response of cells to equibiaxial stretching of micropost arrays. The predicted stress fiber and focal adhesion distributions; in addition to the predicted post tractions are quantitatively and qualitatively supported by previously published experimental data. The computational models presented in this study thus provide a framework for the design and interpretation of experimental micropost studies.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherAmerican Society of Mechanical Engineersen_US
dc.relation.ispartofJournal Of Biomechanical Engineering-Transactions Of The Asmeen
dc.subjectStress fiberen_US
dc.subjectFocal adhesionsen_US
dc.subjectStiffnessen_US
dc.subjectForceen_US
dc.subjectModelen_US
dc.subjectContractilityen_US
dc.subjectCytoskeletonen_US
dc.subjectElasticityen_US
dc.subjectJunctionsen_US
dc.subjectMovementen_US
dc.titleSimulation of the Mechanical Response of Cells on Micropost Substratesen_US
dc.typeArticleen_US
dc.date.updated2014-01-07T18:42:17Z
dc.identifier.doi10.1115/1.4025114
dc.local.publishedsourcehttp://dx.doi.org/10.1115/1.4025114en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid5623683
dc.local.contactPatrick Mcgarry, Mechanical & Biomedical Eng, Eng-3039, New Engineering Building, Nui Galway. 3165 Email: patrick.mcgarry@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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