Clinical applications of gene expression in colorectal cancer.
Kerin, Michael J.
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Kheirelseid EA, Miller N, Chang KH, Nugent M, Kerin MJ (2013) 'Clinical applications of gene expression in colorectal cancer'. Journal of gastrointestinal oncology, 4 (2):144-157.
Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis and response to therapy in CRC is poorly understood. The aims of this study were to quantitatively examine the expression of target genes in colorectal cancer and to correlate their expression levels with clinico-pathological variables.