Show simple item record

dc.contributor.authorKerin, Michael J.
dc.contributor.authorMiller, Nicola
dc.date.accessioned2013-11-27T13:53:43Z
dc.date.available2013-11-27T13:53:43Z
dc.date.issued2013-03-27
dc.identifier.citationMichailidou, K., Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R. L., et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet, 45(4), 353-361.en_US
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/10379/3851
dc.descriptionJournal articleen_US
dc.description.abstractBreast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10!¿8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.en_US
dc.description.sponsorshipEuropean Community Seventh Framework Programme - grant agreement 223175 (HEALTH-F2-2009-223175) (COGS)en_US
dc.formatapplication/docen_US
dc.language.isoenen_US
dc.publisherNature Publishing Group (Macmillan)en_US
dc.relation.ispartofNature Geneticsen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectBreast cancer susceptibilityen_US
dc.subjectGenotypingen_US
dc.titleLarge-scale genotyping identifies 41 new loci associated with breast cancer risk.en_US
dc.typeArticleen_US
dc.date.updated2013-07-03T11:35:52Z
dc.identifier.doi10.1038/ng.2563
dc.local.publishedsourcehttp://dx.doi.org/10.1038/ng.2563en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid3829135
dc.local.contactMichael Kerin, Dept. Of Surgery, Clinical Science Institute, Nui Galway. 87-4203 Email: michael.kerin@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
nui.item.downloads672


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland