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dc.contributor.authorKerin, Michael J.
dc.contributor.authorMiller, Nicola
dc.date.accessioned2013-10-21T11:22:35Z
dc.date.available2013-10-21T11:22:35Z
dc.date.issued2012-07
dc.identifier.citationLambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N et al. (2012) '11q13 is a susceptibility locus for hormone receptor positive breast cancer'. Human mutation, 33 (7):1123-1132.en_US
dc.identifier.issn1098-1004
dc.identifier.urihttp://hdl.handle.net/10379/3765
dc.descriptionJournal articleen_US
dc.description.abstractA recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P â ¤ 3 Ã 10(-9) ) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 Ã 10(-39) ). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.en_US
dc.description.sponsorshipEC Seventh Framework Programme - grant number HEALTH-F2-2009-223175en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHuman mutationen
dc.subjectBreast cancer susceptibilityen_US
dc.subjectPolymorphismsen_US
dc.subjectGenome-wide associationen_US
dc.subjectRisk factorsen_US
dc.subjectHormone receptor statusen_US
dc.subject11q13en_US
dc.title11q13 is a susceptibility locus for hormone receptor positive breast cancer.en_US
dc.typeArticleen_US
dc.date.updated2013-07-03T12:02:41Z
dc.identifier.doi10.1002/humu.22089
dc.local.publishedsourcehttp://dx.doi.org/10.1002/humu.22089en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid2744618
dc.local.contactMichael Kerin, Dept. Of Surgery, Clinical Science Institute, Nui Galway. 87-4203 Email: michael.kerin@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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