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dc.contributor.authorLohfeld, Stefan
dc.contributor.authorCahill, Senan
dc.contributor.authorBarron, Valerie
dc.contributor.authorMcHugh, Peter
dc.date.accessioned2013-09-24T15:10:02Z
dc.date.available2013-09-24T15:10:02Z
dc.date.issued2012
dc.identifier.citationLohfeld, S,Cahill, S,Barron, V,McHugh, P,Durselen, L,Kreja, L,Bausewein, C,Ignatius, A (2012) 'Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds'. Acta Biomaterialia, 8 :3446-3456.en_US
dc.identifier.urihttp://hdl.handle.net/10379/3666
dc.description.abstractThis paper explores the use of selective laser sintering (SLS) for the generation of bone tissue engineering scaffolds from polycaprolactone (PCL) and PCL/tricalcium phosphate (TCP). Different scaffold designs are generated, and assessed from the point of view of manufacturability, porosity and mechanical performance. Large scaffold specimens are produced, with a preferred design, and are assessed through an in vivo study of the critical size bone defect in sheep tibia with subsequent microscopic, histological and mechanical evaluation. Further explorations are performed to generate scaffolds with increasing TCP content. Scaffold fabrication from PCL and PCL/TCP mixtures with up to 50 mass% TCP is shown to be possible. With increasing macroporosity the stiffness of the scaffolds is seen to drop; however, the stiffness can be increased by minor geometrical changes, such as the addition of a cage around the scaffold. In the animal study the selected scaffold for implantation did not perform as well as the TCP control in terms of new bone formation and the resulting mechanical performance of the defect area. A possible cause for this is presented. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.relation.ispartofActa Biomaterialiaen
dc.subjectSelective laser sinteringen_US
dc.subjectBone tissue engineeringen_US
dc.subjectPCLen_US
dc.subjectTCPen_US
dc.subjectMechanical propertiesen_US
dc.titleFabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffoldsen_US
dc.typeArticleen_US
dc.date.updated2013-09-17T11:58:57Z
dc.identifier.doiDOI 10.1016/j.actbio.2012.05.018
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.actbio.2012.05.018en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid2423849
dc.local.contactStefan Lohfeld, Mechanical & Biomedical Eng, Engineering Building Eng-1042, Nui Galway. 2963 Email: stefan.lohfeld@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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