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Diversity and bioactivity of fungi associated with the marine sea cucumber Holothuria poli: disclosing the strains potential for biomedical applications
(Society for Applied Microbiology (SfAM), 2020-04-10)
Aims: Identification of the mycobiota associated to the marine echinoderm Holothuria poli and investigation of cytotoxic and pro-osteogenic potential of isolated strains.
Methods and results: Fungal strains were isolated ...
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
(MDPI, 2020-04-05)
Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney
disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...
The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro
(Frontiers Media, 2020-02-14)
Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ...
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
(Elsevier, 2020-05-29)
Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...
Human monocyte subset distinctions and function: Insights from gene expression analysis
(Frontiers Media, 2020-06-04)
Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ...
Editorial: Innovative biologics and drugs to target renal inflammation
(Frontiers Media, 2020-02-06)
[No abstract available]
Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade
(Elsevier, 2020-01-28)
A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSCs) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study ...
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
(AlphaMed Press and Wiley, 2020-01-29)
The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ...