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Diversity and bioactivity of fungi associated with the marine sea cucumber Holothuria poli: disclosing the strains potential for biomedical applications
(Society for Applied Microbiology (SfAM), 2020-04-10)
Aims: Identification of the mycobiota associated to the marine echinoderm Holothuria poli and investigation of cytotoxic and pro-osteogenic potential of isolated strains.
Methods and results: Fungal strains were isolated ...
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
(MDPI, 2020-04-05)
Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney
disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...
The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro
(Frontiers Media, 2020-02-14)
Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ...
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
(Elsevier, 2020-05-29)
Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...
Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe
(BMJ Publishing Group, 2021-06-14)
Introduction This study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline and to identify indices associated with this decline among adults attending a diabetes center in ...
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
(AlphaMed Press and Wiley, 2020-01-29)
The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ...
Editorial: Innovative biologics and drugs to target renal inflammation
(Frontiers Media, 2020-02-06)
[No abstract available]
Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade
(Elsevier, 2020-01-28)
A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSCs) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study ...
Progress toward the clinical application of mesenchymal stromal cells and other disease-modulating regenerative therapies
(American Society of Nephrology, 2021-01-27)
Drawing from basic knowledge of stem cell biology, embryonic development, wound healing and aging, regenerative medicine seeks to develop therapeutic strategies that complement or replace conventional treatments by actively ...
Current good manufacturing practice considerations for mesenchymal stromal cells as therapeutic agents
(Elsevier, 2021-05-05)
Producing human mesenchymal stromal cells (MSCs) for clinical use requires adherence to current good manufacturing practice (cGMP) standards. This is necessary for ensuring standardization and reproducibility through the ...