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Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
(Springer Verlag, 2015-10-05)
Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ...
Sterile post-traumatic immunosuppression
(Nature Publishing Group, 2016-04-29)
After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...
Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B ) in human arterial smooth muscle cells
(Elsevier, 2015-12-01)
Endothelial nitric oxide synthase (eNOS) is the major source of nitric oxide (NO) production
in blood vessels. One of the pleitropic functions of eNOS derived NO is to inhibit vascular
smooth muscle cell proliferation ...
Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice
(Wiley, 2016-12-28)
Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ...
Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells
(Elsevier, 2016-07-20)
Human bone marrow-derived mesenchymal stromal/stem cells (MSC) have well-documented modulatory effects on multiple immune cell types. Although these effects are linked to their therapeutic benefit in diverse diseases, a ...
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley, 2016-02-27)
The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ...
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
(Springer Verlag, 2015-01-15)
The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ...
Effects of growth phase and temperature on sigma(B) Activity within a Listeria monocytogenes population: evidence for RsbV-independent activation of sigma(B) at refrigeration temperatures
(Hindawi Publishing Corporation, 2014-03-05)
The alternative sigma factor sigma(B) of Listeria monocytogenes is responsible for regulating the transcription of many of the genes necessary for adaptation to both food-related stresses and to conditions found within the ...
Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu.
(Nature Publishing Group, 2013-08)
Investigations into cell therapies for application in organ transplantation have grown. Here, we describe the ex vivo generation of donor bone marrow-derived dendritic cells (BMDCs) and glucocorticoid-treated BMDCs with ...
Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation
(2012)
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential which makes them attractive targets for regenerative medicine applications. However, to date, therapeutic success of MSC-therapy ...