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Sterile post-traumatic immunosuppression

Islam, Md Nahidul; Bradley, Benjamin A.; Ceredig, Rhodri (Nature Publishing Group, 2016-04-29)

After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...

Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus

Griffin, Tomás P.; Islam, Md Nahidul; Blake, Liam; Bell, Marcia; Griffin, Matthew D.; O’Shea, Paula M. (Thieme Publishing, 2018-12-06)

The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ...

Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD).

Hamon, Siobhan M.; Griffin, Tomás P.; Islam, Md Nahidul; Wall, Deirdre; Griffin, Matthew D.; O’Shea, Paula M. (De Gruyter, 2018-09-15)

BACKGROUND: Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative ...

TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo

Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)

Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...

Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe

Griffin, Tomás P.; O'Shea, Paula M.; Smyth, Andrew; Islam, Md Nahidul; Wall, Deirdre; Ferguson, John; O'Sullivan, Esther; Finucane, Francis M.; Dinneen, Sean F.; Dunne, Fidelma P.; Lappin, David W.; Reddan, Donal N.; Bell, Marcia; O'Brien, Timothy; Griffin, Damian G.; Griffin, Matthew D. (BMJ Publishing Group, 2021-06-14)

Introduction This study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline and to identify indices associated with this decline among adults attending a diabetes center in ...

Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers

Islam, Md Nahidul; Griffin, Tomás P.; Sander, Elizabeth; Rocks, Stephanie; Qazi, Junaid; Cabral, Joana; McCaul, Jasmin; McMorrow, Tara; Griffin, Matthew D. (BMC, 2019-11-19)

Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ...

Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential

Griffin, Tomás Patrick; Islam, Md Nahidul; Wall, Deirdre; Ferguson, John; Griffin, Damian Gerard; Griffin, Matthew D.; O’Shea, Paula M. (Nature Research, 2019-12-05)

Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and ...