Now showing items 1-6 of 6
Sterile post-traumatic immunosuppression
(Nature Publishing Group, 2016-04-29)
After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...
Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice
Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ...
Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells
Human bone marrow-derived mesenchymal stromal/stem cells (MSC) have well-documented modulatory effects on multiple immune cell types. Although these effects are linked to their therapeutic benefit in diverse diseases, a ...
Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment
(National Academy of Sciences, 2016-11-04)
Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ...
Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ...
Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression
Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ...