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dc.contributor.authorKerr, D.M.
dc.contributor.authorByrke, N.N.
dc.contributor.authorFord, G.K.
dc.contributor.authorHarhen, B.
dc.contributor.authorHarhen, B.
dc.contributor.authorEgan, L.J.
dc.contributor.authorFinn, David P.
dc.contributor.authorRoche, Michelle
dc.date.accessioned2013-01-21T11:08:53Z
dc.date.available2013-01-21T11:08:53Z
dc.date.issued2012
dc.identifier.citationKerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63.en_US
dc.identifier.urihttp://hdl.handle.net/10379/3176
dc.description.abstractThe endocannabinoid system is an important regulator of the nervous, neuroendocrine and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, there is a paucity of data relating to the effects of endocannabinoids on neuroinflammatory mediators following an immune stress/challenge in vivo. This study investigated the effects of URB597, a selective inhibitor of fatty acid amine hydrolyase (FAAH), the enzyme that preferentially metabolises anandamide, on lipopolysaccharide (LPS)-induced increases in the expression of immune mediators in the hypothalamus. Systemic administration of URB597 increased the levels of anandamide and the related N-acylethanolamines, N-palmitoyl ethanolamide and N-oleoyl ethanolamide, but not 2-arachidonoyl glycerol, in the hypothalamus and spleen. URB597 attenuated the LPS-induced increase in interleukin (IL)-1Beta expression while concurrently augmenting the LPS-induced increase in suppressor of cytokine signalling (SOCS)-3 expression. In addition, URB597 tended to enhance and reduce the LPS-induced increase in IL-6 and IL-10 mRNA expression respectively. LPS-induced increases in peripheral cytokine levels or plasma corticosterone were not altered by URB597. The present study provides evidence for a role for FAAH in the regulation of LPS-induced expression of inflammatory mediators in the hypothalamus. Improved understanding of endocannabinoidmediated regulation of neuroimmune function has fundamental physiological and potential therapeutic significance in the context of stress-related disorders.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.relation.ispartofNeuroscienceen
dc.subjectEndocannabinoiden_US
dc.subjectAnandamideen_US
dc.subject2-AGen_US
dc.subjectCytokineen_US
dc.subjectHPA axisen_US
dc.titlePharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressoren_US
dc.typeArticleen_US
dc.date.updated2013-01-04T14:39:28Z
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.neuroscience.2011.09.032en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid1375739
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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