Show simple item record

dc.contributor.authorMoriarty, Orla
dc.contributor.authorMcGuire, Brian E.
dc.contributor.authorFinn, David P.
dc.date.accessioned2013-01-14T13:25:29Z
dc.date.available2013-01-14T13:25:29Z
dc.date.issued2011
dc.identifier.citationMoriarty O, McGuire BE, Finn DP (2011) 'The effect of pain on cognitive function: a review of clinical and preclinical research'. Progress in Neurobiology, 93 (3):385-404.en_US
dc.identifier.urihttp://hdl.handle.net/10379/3129
dc.description.abstractCognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical and preclinical studies that have investigated pain-related alterations in cognition. These include impaired attentional, executive and general cognitive functioning. We describe the anatomical, neurochemical and molecular substrates common to both cognitive processing and supraspinal pain processing, and present the evidence for their involvement in pain-related cognitive impairment. We also examine the added complexity of cognitive impairment caused by analgesic medications and how this can further impact on morbidity in chronic pain patients. The need for a better understanding of the mechanisms of both pain-induced and treatment-related cognitive impairment is highlighted. Further research in this area will aid our understanding of patient symptoms and their underlying pathophysiology, ultimately leading to increased provision of guided therapy.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.relation.ispartofProgress in Neurobiologyen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectPainen_US
dc.subjectNociceptionen_US
dc.subjectAnalgesiaen_US
dc.subjectCognitionen_US
dc.subjectLearningen_US
dc.subjectMemoryen_US
dc.subjectAttentionen_US
dc.subjectExecutive functionen_US
dc.subjectBrainen_US
dc.subjectRaten_US
dc.subjectHumanen_US
dc.titleThe effect of pain on cognitive function: a review of clinical and preclinical research.en_US
dc.typeArticleen_US
dc.date.updated2013-01-09T15:25:33Z
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.pneurobio.2011.01.002en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid1140971
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
nui.item.downloads6051


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland