The Ryan Institute (Scholarly Articles)
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Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA)
(Elsevier, 2021-07-13)Fasciolosis, a global parasitic disease of agricultural livestock, is caused by the liver fluke Fasciola hepatica. Management and strategic control of fasciolosis on farms depends on early assessment of the extent of disease ... -
Co-selection of bacterial metal and antibiotic resistance in soil laboratory microcosms
(MDPI, 2023-04-18)Accumulation of heavy metals (HMs) in agricultural soil following the application of superphosphate fertilisers seems to induce resistance of soil bacteria to HMs and appears to co-select for resistance to antibiotics (Ab). ... -
Phylogenetic, species richness and logistic influences on the biodiscovery process in Cnidaria
(Frontiers Media, 2022-12-15)The extent to which any particular taxon supplies novel natural products depends on biological and evolutionary differences, and on decisions made by (or constraints on) biodiscovery scientists. The influences of different ... -
PhycoCanopy: An R Shiny tool for exploring primary production in macroalgal canopies
(Wiley, 2022-03-16)1. Macroalgal canopies are considered important for coastal food webs and may have a role in carbon sequestration. Until recently, measures of canopy photosynthesis have been relatively rare, and simulations have sometimes ... -
Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests
(Cambridge University Press, 2021-06-08)The novel coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is the causative agent of the 2020 worldwide coronavirus pandemic. Antibody testing is useful for diagnosing historic infections of a ... -
Born with bristles: New insights on the Kölliker’s organs of Octopus skin
(Frontiers Media, 2021-05-10)The entire skin surface of octopus embryos, hatchlings and juveniles bears scattered tufts of tiny chitinous setae within small pockets, from which they can be everted and retracted. Known as Kölliker’s organs (KO), they ... -
A standardised flexibility assessment methodology for demand response
(Emerald, 2019-05-30)Purpose The purpose of this paper is to present a standardised four-step flexibility assessment methodology for evaluating the available electrical load reduction or increase a building can provide in response to a signal ... -
First record of the elusive oceanic squid Thysanoteuthis rhombus Troschel, 1857 (Cephalopoda: Thysanoteuthidae) in the Catalan coast
(Consejo Superior de Investigaciones Científicas, 2021)The diamondback squid Thysanoteuthis rhombus Troschel, 1857 is a large and elusive oceanic squid spe- cies. Here, we provide the first record of the species for the Catalan coast and integrate this finding in the current ... -
Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (Pf M1AAP) and M17 leucyl aminopeptidase (Pf M17LAP)
(Nature Research, 2021-02-03)The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, PfM1AAP and PfM17LAP, are potential targets for novel anti-malarial drug development. Inhibitors of these aminopeptidases have been shown ... -
Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver
(BMC, 2021-01-11)Background The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and ... -
Morphological and molecular assessments of bobtail squids (Cephalopoda: Sepiolidae) reveal a hidden history of biodiversity
(Frontiers Media, 2021-01-20)Molecular species delimitation assists taxonomic decisions for challenging species, like cryptic species complexes. Bobtail squids (Family Sepiolidae Leach, 1817) are a very diverse group of benthic and nektonic small to ... -
An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica.
(Nature Research, 2020-11-26)Fasciola hepatica is a global parasite of humans and their livestock. Regulation of parasite-secreted cathepsin L-like cysteine proteases associated with virulence is important to fine-tune parasite-host interaction. We ... -
Potentially handicapped but otherwise functional: Malformations in prey capture tools show no impacts on octopus life
(Wiley, 2020-10-17)Larval mortality is a keystone ecological factor for many benthic octopus since it mostly occurs before their settlement in the sea bottom as benthic juveniles. The literature had revealed that records of adult animals ... -
Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)
(Public Library of Science, 2020-07-09)Background Sm16, also known as SPO-1 and SmSLP, is a low molecular weight protein (~16kDa) secreted by the digenean trematode parasite Schistosoma mansoni, one of the main causative agents of human schistosomiasis. The ... -
Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
(Public Library of Science, 2020-08-06)Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica ... -
The invasive land flatworm Obama nungara (Platyhelminthes: Geoplanidae) reaches a natural environment in the oceanic island of São Miguel (Açores)
(Magnolia Press, 2020)We report a new finding of the invasive land flatworm Obama nungara Carbayo et al., 2016 in a natural reserve of the oceanic island of São Miguel (Açores, Portugal) at 947 meters of altitude. This is the first record for ... -
The role of the natural aquatic environment in the dissemination of extended spectrum beta-lactamase and carbapenemase encoding genes: A scoping review
(Elsevier, 2020-05-07)The natural aquatic environment is a significant contributor to the development and circulation of clinically significant antibiotic resistance genes (ARGs). The potential for the aquatic environment to act as a reservoir ... -
Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)
(Public Library of Science, 2020-07-09)Sm16, also known as SPO-1 and SmSLP, is a low molecular weight protein (~16kDa) secreted by the digenean trematode parasite Schistosoma mansoni, one of the main causative agents of human schistosomiasis. The molecule is ... -
Global biodiversity of the genus Ommastrephes (Ommastrephidae: Cephalopoda): an allopatric cryptic species complex
(Oxford University Press (OUP), 2020-03-20)Cryptic speciation among morphologically homogeneous species is a phenomenon increasingly reported in cosmopolitan marine invertebrates. This situation usually leads to the discovery of new species, each of which occupies ...