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dc.contributor.authorDaly, William
dc.contributor.authorYao, Li
dc.contributor.authorZeugolis, Dimitrios
dc.contributor.authorPandit, Abhay
dc.identifier.citationDaly, W., Yao, L., Zeugolis. D.I., Windebank, A. and Pandit, A. (2012) 'A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery'. Journal Of The Royal Society Interface, 9 (67):202-221.en_US
dc.descriptionJournal articleen_US
dc.description.abstractMicrosurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of limitations that need to be addressed. NGCs, in particular, are limited to treating a relatively short nerve gap (4 cm in length) and are often associated with poor functional recovery. Recent advances in biomaterials and tissue engineering approaches are seeking to overcome the limitations associated with these treatment methods. This review critically discusses the advances in biomaterial-based NGCs, their limitations and where future improvements may be required. Recent developments include the incorporation of topographical guidance features and/or intraluminal structures, which attempt to guide Schwann cell (SC) migration and axonal regrowth towards their distal targets. The use of such strategies requires consideration of the size and distribution of these topographical features, as well as a suitable surface for cell-material interactions. Likewise, cellular and molecular-based therapies are being considered for the creation of a more conductive nerve microenvironment. For example, hurdles associated with the short half-lives and low stability of molecular therapies are being surmounted through the use of controlled delivery systems. Similarly, cells (SCs, stem cells and genetically modified cells) are being delivered with biomaterial matrices in attempts to control their dispersion and to facilitate their incorporation within the host regeneration process. Despite recent advances in peripheral nerve repair, there are a number of key factors that need to be considered in order for these new technologies to reach the clinic.en_US
dc.publisherThe Royal Societyen_US
dc.relation.ispartofJournal Of The Royal Society Interfaceen
dc.subjectPeripheral nerve conduiten_US
dc.subjectTopographical guidanceen_US
dc.subjectMolecular therapyen_US
dc.subjectSchwann cellsen_US
dc.subjectStem cellsen_US
dc.subjectNeurotrophic factorsen_US
dc.titleA Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recoveryen_US
dc.local.contactAbhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email:

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