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Now showing items 11-20 of 20
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
(Nature Publishing Group, 2017-10-13)
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these ...
Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit
(Elsevier, 2010-03-21)
Single channel conduits are used clinically in nerve repair as an alternative to the autologous nerve graft. Axons regenerating across single channel tubes, however, may disperse resulting in inappropriate target reinnervation. ...
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
(Royal Society of Chemistry, 2011-01-11)
The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ...
Recent advances in host–guest self‐assembled cyclodextrin carriers: Implications for responsive drug delivery and biomedical engineering
(Wiley, 2020-02-05)
This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical ...
The collagen suprafamily: From biosynthesis to advanced biomaterial development
(Wiley, 2018-08-20)
Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ...
Characterization of the ‘White’ appearing clots that cause acute ischemic stroke
(Elsevier, 2021-09-28)
Objectives
Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the ...
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties
(Springer Nature, 2021-03-19)
Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, ...
Liposomal gene delivery mediated by tissue-engineered scaffolds
(Elsevier, 2010-01-01)
In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as ...
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)
Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ...
A glycotherapeutic approach to functionalize biomaterials-based systems
(Wiley, 2020-03-18)
In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery ...