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Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
(Springer, 2009-01-08)
Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant
morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour
are ...
Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor.
(Sage, 2008)
The regulatory mechanisms underlying myometrial smooth muscle contractility during labor are poorly understood. The authors therefore investigated the transcriptional profile of the changes that occur in the human myometrium ...
Expression of RHOGTPase regulators in human myometrium
(Reproductive Biology and Endocrinology, 2008-01-11)
Background: RHOGTPases play a significant role in modulating myometrial contractility in
uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine
nucleotide exchange factors (RHOGEFs), ...
Effects of combined progesterone and beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
(American Physiological Society, 2015)
A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ...
Analysis of Maxi-K alpha subunit splice variants in human myometrium
(springer, 2004-09-21)
Background: Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated
in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the
regulatory mechanism(s) governing ...
Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use
(2010)
Background: The unique and tuneable photonic properties of Quantum Dots (QDs) have made them potentially useful tools for imaging biological entities. However, QDs though attractive diagnostic and therapeutic tools, have ...
Ghrelin in the human myometrium
(BioMed Central Ltd, 2010-03-29)
Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ...
Differential expression of the metalloproteinase MMP3 and the a5 integrin subunit in human myometrium at labour
(Oxford University Press, 2007-09-13)
Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ...
Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models
(BioMed Central, 2005-03-05)
Background: Many current gene prediction methods use only one model to represent protein-coding regions in a genome, and so are less likely to predict the location of genes that have an atypical sequence composition. It ...
Ghrelin in the human myometrium
(2010)
Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ...