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Type II collagen-hyaluronan hydrogel - a step towards a scaffold for intervertebral disc tissue engineering
(European Cells & Materials Ltd, 2010-09-06)
Intervertebral disc regeneration strategies based on stem cell differentiation in combination with the design of functional scaffolds is an attractive approach towards repairing/regenerating the nucleus pulposus. The ...
A Highly Effective Gene Delivery Vector
(The Royal Society of Chemistry, 2010-06)
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ...
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)
Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ...
Synthesis of polymer-silica hybrid microparticles with defined geometry using surface initiated atom transfer radical polymerization
(Royal Society of Chemistry, 2015)
Nanostructured polymer/silica hybrid materials have gained attention as they combine the advantageous properties of organic and inorganic materials in one entity. Herein, we report incorporation of chloromethyl moieties ...
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)
Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ...
Non-viral gene therapy for myocardial engineering
(John Wiley & Sons, Ltd., 2010-05)
Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ...
Spinal cord injury in vitro: Modelling axon growth inhibition
(Elsevier, 2010-06)
Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. ...
The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility
(Elsevier, 2010-11)
Polymeric hollow spheres can be tailored as efficient carriers of various therapeutic molecules due to their tunable properties. However, the entry of these synthetic vehicles into cells, their cell viability and blood ...
A reliable method for detecting complexed DNA in vitro
(The Royal Society of Chemistry, 2010-09-08)
Quantification of eluted nucleic acids is a critical parameter in characterizing biomaterial based gene-delivery systems. The most commonly used method is to assay samples with an intercalating fluorescent dye such as ...
Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus
(Nature Publishing Group:, 2015-10-22)
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the ...