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Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)
Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ...
Synthesis of polymer-silica hybrid microparticles with defined geometry using surface initiated atom transfer radical polymerization
(Royal Society of Chemistry, 2015)
Nanostructured polymer/silica hybrid materials have gained attention as they combine the advantageous properties of organic and inorganic materials in one entity. Herein, we report incorporation of chloromethyl moieties ...
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)
Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ...
Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus
(Nature Publishing Group:, 2015-10-22)
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the ...
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)
Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ...