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Now showing items 11-20 of 32
When a step is not a step! Specificity analysis of five physical activity monitors
(Public Library of Science, 2017-01-13)
IntroductionPhysical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important ...
Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways
(Elsevier, 2016-04-01)
Emerging evidence suggests a complex interplay between the endocannabinoid system, omega-3 fatty acids and the immune system in the promotion of brain self-repair. However, it is unknown if all omega 3 fatty acids elicit ...
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
(Springer, 2017-03-30)
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ...
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
(Elsevier, 2016-08-31)
Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ...
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
(Elsevier, 2015-03-17)
Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ...
Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid
(Elsevier, 2016-08-31)
Autism spectrum disorders are a group of neurodevelopmental disorders characterised by impaired social interaction, deficits in communication and repetitive stereotyped behaviours. The endocannabinoid system plays an ...
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
(Wiley, 2016-07-12)
A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ...
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer
(Wiley, 2014-11-13)
Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ...
Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
(Elsevier, 2017-01-30)
Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ...
Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation
(Elsevier, 2015-03-28)
The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ...