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Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)
Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ...
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ...
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)
Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ...
Design of a smartphone application with integrated Functional Electrical Stimulation (FES) treatment randomization and On-The-Fly Stimulus Parameter Adjustment for streamlining the clinical evaluation of FES protocols
(OMICS International, 2016-03-14)
The clinical application of Functional Electrical Stimulation (FES) has evolved over the last five decades. However, the use of the Randomized Control Trial (RCT) methodology in evaluating the clinical effectiveness of new ...
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
(Elsevier, 2014-11)
There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ...
Neuroinflammatory mechanisms linking pain and depression
(Karger, 2015)
Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ...
Anandamide modulation of endotoxin-induced inflammation
(OMICS International, 2013-12-20)
The endocannabinoid system is comprised of the CB1
and CB2
receptors, the naturally occurring endogenous ligands, anandamide
(AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes
involved in their synthesis and ...
Detection of ROS induced proteomic signatures by mass spectrometry
(Frontiers Media, 2017)
Reversible and irreversible post-translational modifications ( PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling. Almost ...
Inertial sensor technology for elite swimming performance analysis: a systematic review
(MDPI, 2015-12-25)
Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, ...
These shoes are made for walking: sensitivity performance evaluation of commercial activity monitors under the expected conditions and circumstances required to achieve the international daily step goal of 10,000 steps
(Public Library of Science, 2016-05-11)
IntroductionPhysical activity is a vitally important part of a healthy lifestyle, and is of major benefit to both physical and mental health. A daily step count of 10,000 steps is recommended globally to achieve an appropriate ...