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Detection of ROS induced proteomic signatures by mass spectrometry
(Frontiers Media, 2017)
Reversible and irreversible post-translational modifications ( PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling. Almost ...
When a step is not a step! Specificity analysis of five physical activity monitors
(Public Library of Science, 2017-01-13)
IntroductionPhysical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important ...
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
(Springer, 2017-03-30)
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ...
Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
(Elsevier, 2017-01-30)
Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ...
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
(Bentham Science Publishers, 2017)
Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ...
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)
Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ...
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
(Wiley, 2017-07-20)
Toll-like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3-induced inflammatory, endocrine, and sickness responses. ...
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
(Karger Publishers, 2017-10-24)
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ...
Evaluation of the Finis Swimsense (R) and the Garmin Swim (TM) activity monitors for swimming performance and stroke kinematics analysis
(Public Library of Science, 2017-02-08)
Aims
The study aims were to evaluate the validity of two commercially available swimming activity monitors for quantifying temporal and kinematic swimming variables.
Methods
Ten national level swimmers (5 male, 5 female; ...
Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer
(Public Library of Science, 2017-02-15)
Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, ...