Browsing Physiology by Title
Now showing items 49-68 of 73
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The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse.
(Nature Research, 2019-11-04)The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis. Given ... -
Per pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted-clot-area and histological composition
(BMJ Publishing Group, 2020-12-09)Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic ... -
Pharmacological blockade of PPARα exacerbates inflammatory pain-related impairment of spatial memory in rats
(MDPI, 2021-05-27)Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPAR¿, PPARß/¿ and PPAR¿. Studies suggest that the PPAR signalling system may modulate pain, ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid
(Elsevier, 2016-08-31)Autism spectrum disorders are a group of neurodevelopmental disorders characterised by impaired social interaction, deficits in communication and repetitive stereotyped behaviours. The endocannabinoid system plays an ... -
Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT
(BMJ Publishing Group, 2019-04-05)Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ... -
Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes
(BMJ Publishing Group, 2019-11-04)Background and aims Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS ... -
Platelet-rich emboli in cerebral large vessel occlusion are associated with a large artery atherosclerosis source
(American Heart Association, 2019-05-29)Background and Purpose— Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and ... -
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
(Bentham Science Publishers, 2007)The endogenous polyamines (spermine, spermidine, and putrescine) are present at relatively high concentrations in the mammalian brain and play crucial roles in a variety of aspects of cell functioning. Stroke is the third ... -
Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry based proteomic characterization of formalin-fixed paraffin-embedded blood clots
(Frontiers Media, 2022-04-19)Background and Aims: Besides the crucial role in the treatment of acute ischemic stroke (AIS), mechanical thrombectomy represents a unique opportunity for researchers to study the retrieved clots, with the possibility of ... -
Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models
(BMJ Publishing Group, 2020-06-30)Background Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. Objective To evaluate the navigability and clot retrieval performance of a ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
(Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
(Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
(Wiley, 2013-02-21)Background and Aim TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ... -
A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
(Wiley, 2013-12-05)Background and Purpose The nuclear hormone receptor, PPARα, and its endogenous ligands, are involved in pain modulation. PPARα is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ... -
S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages
(Frontiers Media, 2023-01-23)Background and purpose: Post-thrombectomy intracranial hemorrhages (PTIH) are dangerous complications of acute ischemic stroke (AIS) following mechanical thrombectomy. We aimed to investigate if S100b levels in AIS clots ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
(Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ... -
A standardized aspiration-first approach for thrombectomy to increase speed and improve recanalization rates
(American Society of Neuroradiology, 2019-08-14)BACKGROUND AND PURPOSE: Direct aspiration is a recognized technique for revascularization in large-vessel ischemic strokes. There is ongoing debate regarding its efficacy compared with stent retrievers. Every delay in ... -
Storage of blood clots for histological analysis: How long is too long in saline and paraformaldehyde?
(Universidad de Murcia, 2019)To investigate the composition of blood clots following mechanical thrombectomy, it is essential to ensure optimum storage for highest quality histological and immunofluorescence analysis. We investigated for how long clots ... -
Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
(BMC (part of Springer Nature), 2018-04-10)Background Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ...