Show simple item record

dc.contributor.authorMereuta, Oana Madalina
dc.contributor.authorRossi, Rosanna
dc.contributor.authorDouglas, Andrew
dc.contributor.authorMolina Gil, Sara
dc.contributor.authorFitzgerald, Seán
dc.contributor.authorPandit, Abhay
dc.contributor.authorMcCarthy, Ray
dc.contributor.authorGilvarry, Michael
dc.contributor.authorCeder, Eric
dc.contributor.authorDunker, Dennis
dc.contributor.authorNordanstig, Annika
dc.contributor.authorRedfors, Petra
dc.contributor.authorJood, Katarina
dc.contributor.authorMagoufis, Georgios
dc.contributor.authorPsychogios, Klearchos
dc.contributor.authorTsivgoulis, Georgios
dc.contributor.authorO'Hare, Alan
dc.contributor.authorPower, Sarah
dc.contributor.authorBrennan, Paul
dc.contributor.authorNagy, András
dc.contributor.authorVadász, Ágnes
dc.contributor.authorBrinjikji, Waleed
dc.contributor.authorKallmes, David F.
dc.contributor.authorSzikora, Istvan
dc.contributor.authorRentzos, Alexandros
dc.contributor.authorTatlisumak, Turgut
dc.contributor.authorThornton, John
dc.contributor.authorDoyle, Karen M.
dc.identifier.citationMereuta, Oana Madalina, Rossi, Rosanna, Douglas, Andrew, Gil, Sara Molina, Fitzgerald, Seán, Pandit, Abhay, . . . Doyle, Karen M. (2021). Characterization of the ‘White’ Appearing Clots that Cause Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 30(12), 106127. doi:
dc.description.abstractObjectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the composition, imaging and procedural characteristics of ‘white’ clots retrieved by mechanical thrombectomy. Materials and methods Seventy five ‘white’ thrombi were selected by visual inspection from a cohort of 760 clots collected as part of the RESTORE registry. Clots were evaluated histopathologically. Results Quantification of Martius Scarlett Blue stain identified platelets/other as the major component in ‘white’ clots’ (mean of 55% of clot overall composition) followed by fibrin (31%), red blood cells (6%) and white blood cells (3%). ‘White’ clots contained significantly more platelets/other (p<0.001*) and collagen/calcification (p<0.001*) and less red blood cells (p<0.001*) and white blood cells (p=0.018*) than ‘red’ clots. The mean platelet and von Willebrand Factor expression was 43% and 24%, respectively. Adipocytes were found in four cases. ‘White’ clots were significantly smaller (p=0.016*), less hyperdense (p=0.005*) on computed tomography angiography/non-contrast CT and were associated with a smaller extracted clot area (p<0.001*) than ‘red’ clots. They primarily caused the occlusion of middle cerebral artery, were less likely to be removed by aspiration and more likely to require rescue-therapy for retrieval. Conclusions ‘White’ clots represented 14% of our cohort and were platelet, von Willebrand Factor and collagen/calcification-rich. ‘White’ clots were smaller, less hyperdense, were associated with significantly more distal occlusions and were less successfully removed by aspiration alone than ‘red’ clots.en_IE
dc.description.sponsorshipThis work has emanated from research conducted with the financial support of Science Foundation Ireland and European Regional Development Fund (Grant Number 13/RC/2073_2) and Cerenovus. It was also supported by the National Institutes of Health (R01 NS105853).en_IE
dc.relation.ispartofJournal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National Stroke Associationen
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.subjectIschemic strokeen_IE
dc.subjectMacroscopic appearanceen_IE
dc.subjectMechanical thrombectomyen_IE
dc.titleCharacterization of the ‘White’ appearing clots that cause acute ischemic strokeen_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.contributor.funderNational Institutes of Healthen_IE
dc.local.contactOana Madalina Mereuta. Email:
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)