Audio frequency in vivo optical coherence elastography
Adie, Steven G.
Kennedy, Brendan F.
Armstrong, Julian J.
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Adie, Steven G., Kennedy, Brendan F., Armstrong, Julian J., Alexandrov, Sergey A., & Sampson, David D. (2009). Audio frequencyin vivooptical coherence elastography. Physics in Medicine and Biology, 54(10), 3129-3139. doi: 10.1088/0031-9155/54/10/011
We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.